Digital pathological image analysis and cell segmentation

Luis Hernandez, Paula Gothreaux, George Collins, Liwen Shih, Gerald Campbell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

This project proposes the use of Digital Signal Processing (DSP) for real-time capture and analysis of pathological slide images to improve accuracy and efficiency. Analyzing cell density statistics and average cell nuclei diameters of a slide image is useful to determine the abnormality of slide sample, Being tedious as it is in counting/measuring hundreds to thousands of cells in one sample slide under a microscope, the manual result, typically can be achieved by a pathologist, is often limited by human eye precision/ efficiency. Millions of biopsy samples obtained daily around the world, from minor skin lesions to major tumors, are anxiously waiting to be screened/examined. As a high-level, interactive environment for data visualization/analysis/computation, MATLAB is utilized currently to perform automatic image analysis and segmentation of brain cells on a computer. By comparing cell concentration and cell nuclei sizes between cancerous and normal image groups, MATLAB® can be programmed to distinguish normal brain cells from questionable ones. In general, pathological image analysis using a computer-based application could demonstrate great precision and efficiency for screening large quantities of cells on one or numerous sample slides. Currently, MATLAB® image analysis works on captured/digitized slide images and takes a minute per image to automatically pre-screen abnormalities that require further human expert analysis. With future real-time/parallel/machine-intelligent improvements, we hope that DSP can help physicians/pathologists/patients everywhere to get immediate diagnosis for effective/timely treatment, and can show accuracy within acceptable levels that are comparable to human pathologists in dealing with cell-overlapping and non-cell objects existing in slide images.

Original languageEnglish (US)
Title of host publication2005 IEEE Computational Systems Bioinformatics Conference, Workshops and Poster Abstracts
Number of pages1
DOIs
StatePublished - Dec 1 2005
Externally publishedYes
Event2005 IEEE Computational Systems Bioinformatics Conference, Workshops and Poster Abstracts - Stanford, CA, United States
Duration: Aug 8 2005Aug 11 2005

Publication series

Name2005 IEEE Computational Systems Bioinformatics Conference, Workshops and Poster Abstracts

Other

Other2005 IEEE Computational Systems Bioinformatics Conference, Workshops and Poster Abstracts
CountryUnited States
CityStanford, CA
Period8/8/058/11/05

ASJC Scopus subject areas

  • Engineering(all)

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    Hernandez, L., Gothreaux, P., Collins, G., Shih, L., & Campbell, G. (2005). Digital pathological image analysis and cell segmentation. In 2005 IEEE Computational Systems Bioinformatics Conference, Workshops and Poster Abstracts [1540648] (2005 IEEE Computational Systems Bioinformatics Conference, Workshops and Poster Abstracts). https://doi.org/10.1109/CSBW.2005.52