Diphenyl diselenide attenuates oxidative stress and inflammatory parameters in ulcerative colitis: A comparison with ebselen

Fabricia Petronilho, Monique Michels, Lucinéia G. Danielski, Mariana Pereira Goldim, Drielly Florentino, Andriele Vieira, Mariana G. Mendonça, Moema Tournier, Bárbara Piacentini, Amanda Della Giustina, Daniela D. Leffa, Gregório W. Pereira, Volnei D. Pereira, João Batista Teixeira Da Rocha

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Objetive The aim of this study was to evaluate the effects of diphenyl diselenide (PhSe)2 and ebselen (EB) in ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) in rats. Methods The effects of (PhSe)2 and EB in rats submitted to DSS-induced colitis were determined by measurement of oxidative stress parameters, inflammatory response and bowel histopathological alterations. Results Animals developed moderate to severe neutrophil infiltration in histopathology assay in DSS rats and (PhSe)2 improved this response. Moreover, the treatment with (PhSe)2 decreased the oxidative damage in lipids and proteins, as well as reversed the superoxide dismutase (SOD) and catalase (CAT) levels in rats treated with DSS. EB was able only to reverse damage in lipids and the low levels of SOD in this animal model. Conclusions The organoselenium compounds tested demonstrated an anti-inflammatory and antioxidant activity reducing the colon damage, being (PhSe)2 more effective than EB.

Original languageEnglish (US)
Pages (from-to)755-760
Number of pages6
JournalPathology Research and Practice
Volume212
Issue number9
DOIs
StatePublished - Sep 1 2016
Externally publishedYes

Keywords

  • Diphenyl diselenide
  • DSS induced-colitis
  • Ebselen
  • Oxidative stress
  • Ulcerative colitis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

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