TY - JOUR
T1 - Diphenyl diselenide attenuates oxidative stress and inflammatory parameters in ulcerative colitis
T2 - A comparison with ebselen
AU - Petronilho, Fabricia
AU - Michels, Monique
AU - Danielski, Lucinéia G.
AU - Goldim, Mariana Pereira
AU - Florentino, Drielly
AU - Vieira, Andriele
AU - Mendonça, Mariana G.
AU - Tournier, Moema
AU - Piacentini, Bárbara
AU - Giustina, Amanda Della
AU - Leffa, Daniela D.
AU - Pereira, Gregório W.
AU - Pereira, Volnei D.
AU - Rocha, João Batista Teixeira Da
N1 - Publisher Copyright:
© 2016 Elsevier GmbH
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Objetive The aim of this study was to evaluate the effects of diphenyl diselenide (PhSe)2 and ebselen (EB) in ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) in rats. Methods The effects of (PhSe)2 and EB in rats submitted to DSS-induced colitis were determined by measurement of oxidative stress parameters, inflammatory response and bowel histopathological alterations. Results Animals developed moderate to severe neutrophil infiltration in histopathology assay in DSS rats and (PhSe)2 improved this response. Moreover, the treatment with (PhSe)2 decreased the oxidative damage in lipids and proteins, as well as reversed the superoxide dismutase (SOD) and catalase (CAT) levels in rats treated with DSS. EB was able only to reverse damage in lipids and the low levels of SOD in this animal model. Conclusions The organoselenium compounds tested demonstrated an anti-inflammatory and antioxidant activity reducing the colon damage, being (PhSe)2 more effective than EB.
AB - Objetive The aim of this study was to evaluate the effects of diphenyl diselenide (PhSe)2 and ebselen (EB) in ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) in rats. Methods The effects of (PhSe)2 and EB in rats submitted to DSS-induced colitis were determined by measurement of oxidative stress parameters, inflammatory response and bowel histopathological alterations. Results Animals developed moderate to severe neutrophil infiltration in histopathology assay in DSS rats and (PhSe)2 improved this response. Moreover, the treatment with (PhSe)2 decreased the oxidative damage in lipids and proteins, as well as reversed the superoxide dismutase (SOD) and catalase (CAT) levels in rats treated with DSS. EB was able only to reverse damage in lipids and the low levels of SOD in this animal model. Conclusions The organoselenium compounds tested demonstrated an anti-inflammatory and antioxidant activity reducing the colon damage, being (PhSe)2 more effective than EB.
KW - Diphenyl diselenide
KW - DSS induced-colitis
KW - Ebselen
KW - Oxidative stress
KW - Ulcerative colitis
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U2 - 10.1016/j.prp.2016.04.012
DO - 10.1016/j.prp.2016.04.012
M3 - Article
C2 - 27475409
AN - SCOPUS:84990922166
SN - 0344-0338
VL - 212
SP - 755
EP - 760
JO - Pathology Research and Practice
JF - Pathology Research and Practice
IS - 9
ER -