Diphenyl diselenide attenuates oxidative stress and inflammatory parameters in ulcerative colitis: A comparison with ebselen

Fabricia Petronilho; Monique Michels; Lucinéia G. Danielski; Mariana Pereira Goldim; Drielly Florentino; Andriele Vieira; Mariana G. Mendonça; Moema Tournier; Bárbara Piacentini; Amanda Della Giustina; Daniela D. Leffa; Gregório W. Pereira; Volnei D. Pereira; João Batista Teixeira Da Rocha

doi:10.1016/j.prp.2016.04.012

Diphenyl diselenide attenuates oxidative stress and inflammatory parameters in ulcerative colitis: A comparison with ebselen

Fabricia Petronilho
, Monique Michels
, Lucinéia G. Danielski
, Mariana Pereira Goldim
, Drielly Florentino
, Andriele Vieira
, Mariana G. Mendonça
, Moema Tournier
, Bárbara Piacentini
, Amanda Della Giustina
, Daniela D. Leffa
, Gregório W. Pereira
, Volnei D. Pereira
, João Batista Teixeira Da Rocha

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Objetive The aim of this study was to evaluate the effects of diphenyl diselenide (PhSe)₂ and ebselen (EB) in ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) in rats. Methods The effects of (PhSe)₂ and EB in rats submitted to DSS-induced colitis were determined by measurement of oxidative stress parameters, inflammatory response and bowel histopathological alterations. Results Animals developed moderate to severe neutrophil infiltration in histopathology assay in DSS rats and (PhSe)₂ improved this response. Moreover, the treatment with (PhSe)₂ decreased the oxidative damage in lipids and proteins, as well as reversed the superoxide dismutase (SOD) and catalase (CAT) levels in rats treated with DSS. EB was able only to reverse damage in lipids and the low levels of SOD in this animal model. Conclusions The organoselenium compounds tested demonstrated an anti-inflammatory and antioxidant activity reducing the colon damage, being (PhSe)₂ more effective than EB.

Original language	English (US)
Pages (from-to)	755-760
Number of pages	6
Journal	Pathology Research and Practice
Volume	212
Issue number	9
DOIs	https://doi.org/10.1016/j.prp.2016.04.012
State	Published - Sep 1 2016
Externally published	Yes

Keywords

Diphenyl diselenide
DSS induced-colitis
Ebselen
Oxidative stress
Ulcerative colitis

ASJC Scopus subject areas

Pathology and Forensic Medicine
Cell Biology

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10.1016/j.prp.2016.04.012

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Petronilho, F., Michels, M., Danielski, L. G., Goldim, M. P., Florentino, D., Vieira, A., Mendonça, M. G., Tournier, M., Piacentini, B., Giustina, A. D., Leffa, D. D., Pereira, G. W., Pereira, V. D., & Rocha, J. B. T. D. (2016). Diphenyl diselenide attenuates oxidative stress and inflammatory parameters in ulcerative colitis: A comparison with ebselen. Pathology Research and Practice, 212(9), 755-760. https://doi.org/10.1016/j.prp.2016.04.012

Petronilho, F, Michels, M, Danielski, LG, Goldim, MP, Florentino, D, Vieira, A, Mendonça, MG, Tournier, M, Piacentini, B, Giustina, AD, Leffa, DD, Pereira, GW, Pereira, VD & Rocha, JBTD 2016, 'Diphenyl diselenide attenuates oxidative stress and inflammatory parameters in ulcerative colitis: A comparison with ebselen', Pathology Research and Practice, vol. 212, no. 9, pp. 755-760. https://doi.org/10.1016/j.prp.2016.04.012

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title = "Diphenyl diselenide attenuates oxidative stress and inflammatory parameters in ulcerative colitis: A comparison with ebselen",

abstract = "Objetive The aim of this study was to evaluate the effects of diphenyl diselenide (PhSe)2 and ebselen (EB) in ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) in rats. Methods The effects of (PhSe)2 and EB in rats submitted to DSS-induced colitis were determined by measurement of oxidative stress parameters, inflammatory response and bowel histopathological alterations. Results Animals developed moderate to severe neutrophil infiltration in histopathology assay in DSS rats and (PhSe)2 improved this response. Moreover, the treatment with (PhSe)2 decreased the oxidative damage in lipids and proteins, as well as reversed the superoxide dismutase (SOD) and catalase (CAT) levels in rats treated with DSS. EB was able only to reverse damage in lipids and the low levels of SOD in this animal model. Conclusions The organoselenium compounds tested demonstrated an anti-inflammatory and antioxidant activity reducing the colon damage, being (PhSe)2 more effective than EB.",

keywords = "Diphenyl diselenide, DSS induced-colitis, Ebselen, Oxidative stress, Ulcerative colitis",

author = "Fabricia Petronilho and Monique Michels and Danielski, \{Lucin{\'e}ia G.\} and Goldim, \{Mariana Pereira\} and Drielly Florentino and Andriele Vieira and Mendon{\c c}a, \{Mariana G.\} and Moema Tournier and B{\'a}rbara Piacentini and Giustina, \{Amanda Della\} and Leffa, \{Daniela D.\} and Pereira, \{Greg{\'o}rio W.\} and Pereira, \{Volnei D.\} and Rocha, \{Jo{\~a}o Batista Teixeira Da\}",

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year = "2016",

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doi = "10.1016/j.prp.2016.04.012",

language = "English (US)",

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T1 - Diphenyl diselenide attenuates oxidative stress and inflammatory parameters in ulcerative colitis

T2 - A comparison with ebselen

AU - Petronilho, Fabricia

AU - Michels, Monique

AU - Danielski, Lucinéia G.

AU - Goldim, Mariana Pereira

AU - Florentino, Drielly

AU - Vieira, Andriele

AU - Mendonça, Mariana G.

AU - Tournier, Moema

AU - Piacentini, Bárbara

AU - Giustina, Amanda Della

AU - Leffa, Daniela D.

AU - Pereira, Gregório W.

AU - Pereira, Volnei D.

AU - Rocha, João Batista Teixeira Da

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Objetive The aim of this study was to evaluate the effects of diphenyl diselenide (PhSe)2 and ebselen (EB) in ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) in rats. Methods The effects of (PhSe)2 and EB in rats submitted to DSS-induced colitis were determined by measurement of oxidative stress parameters, inflammatory response and bowel histopathological alterations. Results Animals developed moderate to severe neutrophil infiltration in histopathology assay in DSS rats and (PhSe)2 improved this response. Moreover, the treatment with (PhSe)2 decreased the oxidative damage in lipids and proteins, as well as reversed the superoxide dismutase (SOD) and catalase (CAT) levels in rats treated with DSS. EB was able only to reverse damage in lipids and the low levels of SOD in this animal model. Conclusions The organoselenium compounds tested demonstrated an anti-inflammatory and antioxidant activity reducing the colon damage, being (PhSe)2 more effective than EB.

AB - Objetive The aim of this study was to evaluate the effects of diphenyl diselenide (PhSe)2 and ebselen (EB) in ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) in rats. Methods The effects of (PhSe)2 and EB in rats submitted to DSS-induced colitis were determined by measurement of oxidative stress parameters, inflammatory response and bowel histopathological alterations. Results Animals developed moderate to severe neutrophil infiltration in histopathology assay in DSS rats and (PhSe)2 improved this response. Moreover, the treatment with (PhSe)2 decreased the oxidative damage in lipids and proteins, as well as reversed the superoxide dismutase (SOD) and catalase (CAT) levels in rats treated with DSS. EB was able only to reverse damage in lipids and the low levels of SOD in this animal model. Conclusions The organoselenium compounds tested demonstrated an anti-inflammatory and antioxidant activity reducing the colon damage, being (PhSe)2 more effective than EB.

KW - Diphenyl diselenide

KW - DSS induced-colitis

KW - Ebselen

KW - Oxidative stress

KW - Ulcerative colitis

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Diphenyl diselenide attenuates oxidative stress and inflammatory parameters in ulcerative colitis: A comparison with ebselen

Abstract

Keywords

ASJC Scopus subject areas

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