Discovery and development of natural product oridonin-inspired anticancer agents

Ye Ding, Chunyong Ding, Na Ye, Zhiqing Liu, Eric A. Wold, Haiying Chen, Christopher Wild, Qiang Shen, Jia Zhou

Research output: Contribution to journalReview article

53 Citations (Scopus)

Abstract

Natural products have historically been, and continue to be, an invaluable source for the discovery of various therapeutic agents. Oridonin, a natural diterpenoid widely applied in traditional Chinese medicines, exhibits a broad range of biological effects including anticancer and anti-inflammatory activities. To further improve its potency, aqueous solubility and bioavailability, the oridonin template serves as an exciting platform for drug discovery to yield better candidates with unique targets and enhanced drug properties. A number of oridonin derivatives (e.g. HAO472) have been designed and synthesized, and have contributed to substantial progress in the identification of new agents and relevant molecular mechanistic studies toward the treatment of human cancers and other diseases. This review summarizes the recent advances in medicinal chemistry on the explorations of novel oridonin analogues as potential anticancer therapeutics, and provides a detailed discussion of future directions for the development and progression of this class of molecules into the clinic.

Original languageEnglish (US)
Pages (from-to)102-117
Number of pages16
JournalEuropean Journal of Medicinal Chemistry
Volume122
DOIs
StatePublished - Oct 21 2016

Fingerprint

Biological Products
Antineoplastic Agents
Pharmaceutical Chemistry
Diterpenes
Chinese Traditional Medicine
Drug Discovery
Solubility
Biological Availability
Medicine
Anti-Inflammatory Agents
Therapeutics
Derivatives
Molecules
oridonin
Pharmaceutical Preparations
Neoplasms

Keywords

  • Anticancer agents
  • Chemical biology
  • Diterpenoids
  • Drug discovery
  • Natural product
  • Oridonin

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Discovery and development of natural product oridonin-inspired anticancer agents. / Ding, Ye; Ding, Chunyong; Ye, Na; Liu, Zhiqing; Wold, Eric A.; Chen, Haiying; Wild, Christopher; Shen, Qiang; Zhou, Jia.

In: European Journal of Medicinal Chemistry, Vol. 122, 21.10.2016, p. 102-117.

Research output: Contribution to journalReview article

Ding, Ye ; Ding, Chunyong ; Ye, Na ; Liu, Zhiqing ; Wold, Eric A. ; Chen, Haiying ; Wild, Christopher ; Shen, Qiang ; Zhou, Jia. / Discovery and development of natural product oridonin-inspired anticancer agents. In: European Journal of Medicinal Chemistry. 2016 ; Vol. 122. pp. 102-117.
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