Discovery and Functional Characterization of a Potent, Selective, and Metabolically Stable PROTAC of the Protein Kinases DYRK1A and DYRK1B

Keyphrases

• Protein Kinase 100%
• Functional Characterization 100%
• DYRK1A 100%
• Proteolysis Targeting chimera (PROTAC) 100%
• Metabolically Stable 100%
• DYRK1 30%
• Ubiquitination 10%
• Neurodegeneration 10%
• Cell-based 10%
• Adaptive Immune Response 10%
• Small Molecules 10%
• Pathological Process 10%
• Cancer Development 10%
• Efficient Degradation 10%
• Splice Variant 10%
• Relevant Protein 10%
• Kinase Inhibition 10%
• Proteasomal Degradation 10%
• Downstream Signaling 10%
• Chemical Probes 10%
• Immune Homeostasis 10%
• E3 Ubiquitin Ligase 10%
• Useful Chemicals 10%
• Fast Degradation 10%
• Targeted Degradation 10%
• Selective Degradation 10%
• ATP-competitive 10%
• Cereblon 10%
• Induced Protein Degradation 10%

Biochemistry, Genetics and Molecular Biology

• Protein Kinases 100%
• Proteolysis 100%
• DYRK1A 100%
• Adenosine Triphosphate 20%
• Ubiquitination 20%
• Homeostasis 20%
• Phosphotransferase 20%
• Protein Catabolism 20%
• Kinase 20%
• Small Molecule 20%
• Ubiquitin-Conjugating Enzyme 20%
• Cereblon 20%