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Discovery of novel chemical scaffolds as RhoA inhibitors using virtual screening, synthesis, and bioactivity evaluation
Chao Zhang
, Hui Jie Wang
, Qi Chao Bao
, Jin Lei Bian
, Ying Rui Yang
, Qi Dong You
, Xiao Li Xu
Research output
:
Contribution to journal
›
Article
›
peer-review
1
Scopus citations
Overview
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Keyphrases
Synthetic Evaluation
100%
Virtual Screening
100%
Novel Chemicals
100%
Chemical Scaffolds
100%
Screening Assessment
100%
RhoA
100%
RhoA Inhibitor
100%
Bioactivity Scores
100%
Physiological Role
20%
Cell Behavior
20%
Structural Modification
20%
Small Molecule Inhibitors
20%
Binding Activity
20%
Breast Cancer Cells
20%
Proglumide
20%
Rationally Designed
20%
Inhibition Activity
20%
Clinical Development
20%
Approved Drugs
20%
Pathological Role
20%
Rho GTPases
20%
Cancer Therapeutic Target
20%
Pharmacology, Toxicology and Pharmaceutical Science
Virtual Screening
100%
Malignant Neoplasm
50%
Breast Cancer
50%
Proglumide
50%
Rho Guanine Nucleotide Binding Protein
50%