Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation

Keyphrases

• Toll-like Receptor 3 (TLR3) 100%
• Airway Inflammation 100%
• BRD4 Inhibitor 100%
• Bromodomain-containing Protein 4 (BRD4) 66%
• Hydrogen Bonds (H-bonds) 33%
• Mouse Model 33%
• Therapeutic Potential 33%
• Small Molecules 33%
• Viral 33%
• Interleukin-8 33%
• Low Toxicity 33%
• Human Small Airway Epithelial Cells 33%
• Binding Affinity 33%
• Binding Pocket 33%
• Structure-based Drug Design 33%
• Innate Immune Genes 33%
• Acetyl-lysine 33%
• Gene Programs 33%
• ISG54 33%
• ISG56 33%
• Bromodomain 33%
• Fragment Merging 33%
• H2O Molecule 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Respiratory Tract Inflammation 100%
• Toll Like Receptor 3 100%
• Acetic Acid Derivative 33%
• Mouse Model 33%
• Drug Development 33%
• Hydrogen Bond 33%
• Lysine 33%