Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design

Fumiaki Yokokawa, Shahul Nilar, Christian G. Noble, Siew Pheng Lim, Ranga Rao, Stefani Tania, Gang Wang, Gladys Lee, Jürg Hunziker, Ratna Karuna, Ujjini Manjunatha, Pei-Yong Shi, Paul W. Smith

Research output: Contribution to journalArticle

38 Scopus citations
Original languageEnglish (US)
Pages (from-to)3935-3952
Number of pages18
JournalJournal of Medicinal Chemistry
Volume59
Issue number8
DOIs
StatePublished - Apr 28 2016

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Cite this

Yokokawa, F., Nilar, S., Noble, C. G., Lim, S. P., Rao, R., Tania, S., Wang, G., Lee, G., Hunziker, J., Karuna, R., Manjunatha, U., Shi, P-Y., & Smith, P. W. (2016). Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design. Journal of Medicinal Chemistry, 59(8), 3935-3952. https://doi.org/10.1021/acs.jmedchem.6b00143