Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design

Keyphrases

• RNA-dependent RNA Polymerase (RdRP) 100%
• Dengue 100%
• Structure-based Drug Design 100%
• Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI) 100%
• Viral RNA-dependent RNA Polymerase 100%
• Fragment Hits 100%
• Cell-based 50%
• Clinically Significant 50%
• X-ray 50%
• Binding Pocket 50%
• EC50 50%
• Acetic Acid 50%
• Ray-based 50%
• Structure-based Design 50%
• Dengue Serotypes 50%
• RNA Polymerase Inhibitor 50%
• Biphenyl 50%
• Anti-dengue Activity 50%
• Novartis 50%
• Fragment Screen 50%
• Non-nucleoside 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Dengue 100%
• Virus RNA 100%
• RNA Directed RNA Polymerase 100%
• Nucleoside 100%
• Structure-Based Drug Design 100%
• Potassium Acetate 33%
• Biphenyl 33%
• EC50 33%
• RNA Directed RNA Polymerase Inhibitor 33%