Discovery of swine as a host for the reston ebolavirus

Roger W. Barrette, Samia A. Metwally, Jessica M. Rowland, Lizhe Xu, Sherif R. Zaki, Stuart T. Nichol, Pierre E. Rollin, Jonathan S. Towner, Wun Ju Shieh, Brigid Batten, Tara K. Sealy, Consuelo Carrillo, Karen E. Moran, Alexa J. Bracht, Gregory A. Mayr, Magdalena Sirios-Cruz, Davinio P. Catbagan, Elizabeth A. Lautner, Thomas Ksiazek, William R. White & 1 others Michael T. Mcintosh

Research output: Contribution to journalArticle

245 Citations (Scopus)

Abstract

Since the discovery of the Marburg and Ebola species of filovirus, seemingly random, sporadic fatal outbreaks of disease in humans and nonhuman primates have given impetus to identification of host tropisms and potential reservoirs. Domestic swine in the Philippines, experiencing unusually severe outbreaks of porcine reproductive and respiratory disease syndrome, have now been discovered to host Reston ebolavirus (REBOV). Although REBOV is the only member of Filoviridae that has not been associated with disease in humans, its emergence in the human food chain is of concern. REBOV isolates were found to be more divergent from each other than from the original virus isolated in 1989, indicating polyphyletic origins and that REBOV has been circulating since, and possibly before, the initial discovery of REBOV in monkeys.

Original languageEnglish (US)
Pages (from-to)204-206
Number of pages3
JournalScience
Volume325
Issue number5937
DOIs
StatePublished - Jul 10 2009

Fingerprint

Ebolavirus
Swine
Disease Outbreaks
Filoviridae
Viral Tropism
Porcine Reproductive and Respiratory Syndrome
Philippines
Food Chain
Primates
Haplorhini
Reston
Viruses

ASJC Scopus subject areas

  • General

Cite this

Barrette, R. W., Metwally, S. A., Rowland, J. M., Xu, L., Zaki, S. R., Nichol, S. T., ... Mcintosh, M. T. (2009). Discovery of swine as a host for the reston ebolavirus. Science, 325(5937), 204-206. https://doi.org/10.1126/science.1172705

Discovery of swine as a host for the reston ebolavirus. / Barrette, Roger W.; Metwally, Samia A.; Rowland, Jessica M.; Xu, Lizhe; Zaki, Sherif R.; Nichol, Stuart T.; Rollin, Pierre E.; Towner, Jonathan S.; Shieh, Wun Ju; Batten, Brigid; Sealy, Tara K.; Carrillo, Consuelo; Moran, Karen E.; Bracht, Alexa J.; Mayr, Gregory A.; Sirios-Cruz, Magdalena; Catbagan, Davinio P.; Lautner, Elizabeth A.; Ksiazek, Thomas; White, William R.; Mcintosh, Michael T.

In: Science, Vol. 325, No. 5937, 10.07.2009, p. 204-206.

Research output: Contribution to journalArticle

Barrette, RW, Metwally, SA, Rowland, JM, Xu, L, Zaki, SR, Nichol, ST, Rollin, PE, Towner, JS, Shieh, WJ, Batten, B, Sealy, TK, Carrillo, C, Moran, KE, Bracht, AJ, Mayr, GA, Sirios-Cruz, M, Catbagan, DP, Lautner, EA, Ksiazek, T, White, WR & Mcintosh, MT 2009, 'Discovery of swine as a host for the reston ebolavirus', Science, vol. 325, no. 5937, pp. 204-206. https://doi.org/10.1126/science.1172705
Barrette RW, Metwally SA, Rowland JM, Xu L, Zaki SR, Nichol ST et al. Discovery of swine as a host for the reston ebolavirus. Science. 2009 Jul 10;325(5937):204-206. https://doi.org/10.1126/science.1172705
Barrette, Roger W. ; Metwally, Samia A. ; Rowland, Jessica M. ; Xu, Lizhe ; Zaki, Sherif R. ; Nichol, Stuart T. ; Rollin, Pierre E. ; Towner, Jonathan S. ; Shieh, Wun Ju ; Batten, Brigid ; Sealy, Tara K. ; Carrillo, Consuelo ; Moran, Karen E. ; Bracht, Alexa J. ; Mayr, Gregory A. ; Sirios-Cruz, Magdalena ; Catbagan, Davinio P. ; Lautner, Elizabeth A. ; Ksiazek, Thomas ; White, William R. ; Mcintosh, Michael T. / Discovery of swine as a host for the reston ebolavirus. In: Science. 2009 ; Vol. 325, No. 5937. pp. 204-206.
@article{abe87c44d9de47aaa395d76e3a586195,
title = "Discovery of swine as a host for the reston ebolavirus",
abstract = "Since the discovery of the Marburg and Ebola species of filovirus, seemingly random, sporadic fatal outbreaks of disease in humans and nonhuman primates have given impetus to identification of host tropisms and potential reservoirs. Domestic swine in the Philippines, experiencing unusually severe outbreaks of porcine reproductive and respiratory disease syndrome, have now been discovered to host Reston ebolavirus (REBOV). Although REBOV is the only member of Filoviridae that has not been associated with disease in humans, its emergence in the human food chain is of concern. REBOV isolates were found to be more divergent from each other than from the original virus isolated in 1989, indicating polyphyletic origins and that REBOV has been circulating since, and possibly before, the initial discovery of REBOV in monkeys.",
author = "Barrette, {Roger W.} and Metwally, {Samia A.} and Rowland, {Jessica M.} and Lizhe Xu and Zaki, {Sherif R.} and Nichol, {Stuart T.} and Rollin, {Pierre E.} and Towner, {Jonathan S.} and Shieh, {Wun Ju} and Brigid Batten and Sealy, {Tara K.} and Consuelo Carrillo and Moran, {Karen E.} and Bracht, {Alexa J.} and Mayr, {Gregory A.} and Magdalena Sirios-Cruz and Catbagan, {Davinio P.} and Lautner, {Elizabeth A.} and Thomas Ksiazek and White, {William R.} and Mcintosh, {Michael T.}",
year = "2009",
month = "7",
day = "10",
doi = "10.1126/science.1172705",
language = "English (US)",
volume = "325",
pages = "204--206",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5937",

}

TY - JOUR

T1 - Discovery of swine as a host for the reston ebolavirus

AU - Barrette, Roger W.

AU - Metwally, Samia A.

AU - Rowland, Jessica M.

AU - Xu, Lizhe

AU - Zaki, Sherif R.

AU - Nichol, Stuart T.

AU - Rollin, Pierre E.

AU - Towner, Jonathan S.

AU - Shieh, Wun Ju

AU - Batten, Brigid

AU - Sealy, Tara K.

AU - Carrillo, Consuelo

AU - Moran, Karen E.

AU - Bracht, Alexa J.

AU - Mayr, Gregory A.

AU - Sirios-Cruz, Magdalena

AU - Catbagan, Davinio P.

AU - Lautner, Elizabeth A.

AU - Ksiazek, Thomas

AU - White, William R.

AU - Mcintosh, Michael T.

PY - 2009/7/10

Y1 - 2009/7/10

N2 - Since the discovery of the Marburg and Ebola species of filovirus, seemingly random, sporadic fatal outbreaks of disease in humans and nonhuman primates have given impetus to identification of host tropisms and potential reservoirs. Domestic swine in the Philippines, experiencing unusually severe outbreaks of porcine reproductive and respiratory disease syndrome, have now been discovered to host Reston ebolavirus (REBOV). Although REBOV is the only member of Filoviridae that has not been associated with disease in humans, its emergence in the human food chain is of concern. REBOV isolates were found to be more divergent from each other than from the original virus isolated in 1989, indicating polyphyletic origins and that REBOV has been circulating since, and possibly before, the initial discovery of REBOV in monkeys.

AB - Since the discovery of the Marburg and Ebola species of filovirus, seemingly random, sporadic fatal outbreaks of disease in humans and nonhuman primates have given impetus to identification of host tropisms and potential reservoirs. Domestic swine in the Philippines, experiencing unusually severe outbreaks of porcine reproductive and respiratory disease syndrome, have now been discovered to host Reston ebolavirus (REBOV). Although REBOV is the only member of Filoviridae that has not been associated with disease in humans, its emergence in the human food chain is of concern. REBOV isolates were found to be more divergent from each other than from the original virus isolated in 1989, indicating polyphyletic origins and that REBOV has been circulating since, and possibly before, the initial discovery of REBOV in monkeys.

UR - http://www.scopus.com/inward/record.url?scp=67650439331&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67650439331&partnerID=8YFLogxK

U2 - 10.1126/science.1172705

DO - 10.1126/science.1172705

M3 - Article

VL - 325

SP - 204

EP - 206

JO - Science

JF - Science

SN - 0036-8075

IS - 5937

ER -