Discovery of swine as a host for the reston ebolavirus

Roger W. Barrette; Samia A. Metwally; Jessica M. Rowland; Lizhe Xu; Sherif R. Zaki; Stuart T. Nichol; Pierre E. Rollin; Jonathan S. Towner; Wun Ju Shieh; Brigid Batten; Tara K. Sealy; Consuelo Carrillo; Karen E. Moran; Alexa J. Bracht; Gregory A. Mayr; Magdalena Sirios-Cruz; Davinio P. Catbagan; Elizabeth A. Lautner; Thomas G. Ksiazek; William R. White; Michael T. Mcintosh

doi:10.1126/science.1172705

Discovery of swine as a host for the reston ebolavirus

Roger W. Barrette, Samia A. Metwally, Jessica M. Rowland, Lizhe Xu, Sherif R. Zaki, Stuart T. Nichol, Pierre E. Rollin, Jonathan S. Towner, Wun Ju Shieh, Brigid Batten, Tara K. Sealy, Consuelo Carrillo, Karen E. Moran, Alexa J. Bracht, Gregory A. Mayr, Magdalena Sirios-Cruz, Davinio P. Catbagan, Elizabeth A. Lautner, Thomas G. Ksiazek, William R. WhiteMichael T. Mcintosh

Pathology

Research output: Contribution to journal › Article › peer-review

344 Scopus citations

Abstract

Since the discovery of the Marburg and Ebola species of filovirus, seemingly random, sporadic fatal outbreaks of disease in humans and nonhuman primates have given impetus to identification of host tropisms and potential reservoirs. Domestic swine in the Philippines, experiencing unusually severe outbreaks of porcine reproductive and respiratory disease syndrome, have now been discovered to host Reston ebolavirus (REBOV). Although REBOV is the only member of Filoviridae that has not been associated with disease in humans, its emergence in the human food chain is of concern. REBOV isolates were found to be more divergent from each other than from the original virus isolated in 1989, indicating polyphyletic origins and that REBOV has been circulating since, and possibly before, the initial discovery of REBOV in monkeys.

Original language	English (US)
Pages (from-to)	204-206
Number of pages	3
Journal	Science
Volume	325
Issue number	5937
DOIs	https://doi.org/10.1126/science.1172705
State	Published - Jul 10 2009

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Barrette, R. W., Metwally, S. A., Rowland, J. M., Xu, L., Zaki, S. R., Nichol, S. T., Rollin, P. E., Towner, J. S., Shieh, W. J., Batten, B., Sealy, T. K., Carrillo, C., Moran, K. E., Bracht, A. J., Mayr, G. A., Sirios-Cruz, M., Catbagan, D. P., Lautner, E. A., Ksiazek, T. G., ... Mcintosh, M. T. (2009). Discovery of swine as a host for the reston ebolavirus. Science, 325(5937), 204-206. https://doi.org/10.1126/science.1172705

Barrette, RW, Metwally, SA, Rowland, JM, Xu, L, Zaki, SR, Nichol, ST, Rollin, PE, Towner, JS, Shieh, WJ, Batten, B, Sealy, TK, Carrillo, C, Moran, KE, Bracht, AJ, Mayr, GA, Sirios-Cruz, M, Catbagan, DP, Lautner, EA, Ksiazek, TG, White, WR & Mcintosh, MT 2009, 'Discovery of swine as a host for the reston ebolavirus', Science, vol. 325, no. 5937, pp. 204-206. https://doi.org/10.1126/science.1172705

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abstract = "Since the discovery of the Marburg and Ebola species of filovirus, seemingly random, sporadic fatal outbreaks of disease in humans and nonhuman primates have given impetus to identification of host tropisms and potential reservoirs. Domestic swine in the Philippines, experiencing unusually severe outbreaks of porcine reproductive and respiratory disease syndrome, have now been discovered to host Reston ebolavirus (REBOV). Although REBOV is the only member of Filoviridae that has not been associated with disease in humans, its emergence in the human food chain is of concern. REBOV isolates were found to be more divergent from each other than from the original virus isolated in 1989, indicating polyphyletic origins and that REBOV has been circulating since, and possibly before, the initial discovery of REBOV in monkeys.",

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AU - Moran, Karen E.

AU - Bracht, Alexa J.

AU - Mayr, Gregory A.

AU - Sirios-Cruz, Magdalena

AU - Catbagan, Davinio P.

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Discovery of swine as a host for the reston ebolavirus

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