Discriminative stimulus properties of clonidine

Substitution by ergot derivatives

Kathryn Cunningham, Patrick M. Callahan, Nancy A. Craigmyle, James B. Appel

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Bromocriptine, lergotrile and lisuride but not apomorphine, ergonovine or lysergic acid diethylamide (LSD) mimicked clonidine in rats trained to discriminate this compound (0.02 mg/kg) from saline. BC 105, ketanserin and haloperidol failed to block the clonidine cue. Yohimbine was an effective antagonist of clonidine but not of the lisuride substitution for clonidine. Since dopamine does not appear to be involved in the stimulus effects of clonidine, the behavioral similarities between clonidine and some ergots may be related to α-adrenoceptor stimulation; however, the role of blood pressure changes in the stimulus effects of all these of compunds should not be overlooked.

Original languageEnglish (US)
Pages (from-to)225-229
Number of pages5
JournalEuropean Journal of Pharmacology
Volume119
Issue number3
DOIs
StatePublished - Dec 17 1985
Externally publishedYes

Fingerprint

Clonidine
Lisuride
Pizotyline
Ergonovine
Ketanserin
Lysergic Acid Diethylamide
Yohimbine
Bromocriptine
Apomorphine
Haloperidol
Adrenergic Receptors
Cues
Dopamine
Blood Pressure

Keywords

  • Bromocriptine
  • Clonidine
  • d-Lysergic acid diethylamide (LSD)
  • Dopamine
  • Drug discrimination
  • Lergotrile
  • Lisuride
  • α-Adrenoceptors

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Discriminative stimulus properties of clonidine : Substitution by ergot derivatives. / Cunningham, Kathryn; Callahan, Patrick M.; Craigmyle, Nancy A.; Appel, James B.

In: European Journal of Pharmacology, Vol. 119, No. 3, 17.12.1985, p. 225-229.

Research output: Contribution to journalArticle

Cunningham, Kathryn ; Callahan, Patrick M. ; Craigmyle, Nancy A. ; Appel, James B. / Discriminative stimulus properties of clonidine : Substitution by ergot derivatives. In: European Journal of Pharmacology. 1985 ; Vol. 119, No. 3. pp. 225-229.
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