Discriminative stimulus properties of clonidine: Substitution by ergot derivatives

Kathryn A. Cunningham, Patrick M. Callahan, Nancy A. Craigmyle, James B. Appel

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Bromocriptine, lergotrile and lisuride but not apomorphine, ergonovine or lysergic acid diethylamide (LSD) mimicked clonidine in rats trained to discriminate this compound (0.02 mg/kg) from saline. BC 105, ketanserin and haloperidol failed to block the clonidine cue. Yohimbine was an effective antagonist of clonidine but not of the lisuride substitution for clonidine. Since dopamine does not appear to be involved in the stimulus effects of clonidine, the behavioral similarities between clonidine and some ergots may be related to α-adrenoceptor stimulation; however, the role of blood pressure changes in the stimulus effects of all these of compunds should not be overlooked.

Original languageEnglish (US)
Pages (from-to)225-229
Number of pages5
JournalEuropean Journal of Pharmacology
Volume119
Issue number3
DOIs
StatePublished - Dec 17 1985
Externally publishedYes

Keywords

  • Bromocriptine
  • Clonidine
  • Dopamine
  • Drug discrimination
  • Lergotrile
  • Lisuride
  • d-Lysergic acid diethylamide (LSD)
  • α-Adrenoceptors

ASJC Scopus subject areas

  • Pharmacology

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