Disease modeling for Ebola and Marburg viruses

Dennis Bente, Jason Gren, James E. Strong, Heinz Feldmann

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

The filoviruses Ebola and Marburg are zoonotic agents that are classified as both biosafety level 4 and category A list pathogens. These viruses are pathogenic in humans and cause isolated infections or epidemics of viral hemorrhagic fever, mainly in Central Africa. Their natural reservoir has not been definitely identified, but certain species of African bat have been associated with Ebola and Marburg infections. Currently, there are no licensed options available for either treatment or prophylaxis. Different animal models have been developed for filoviruses including mouse, guinea pig and nonhuman primates. The 'gold standard' animal models for pathogenesis, treatment and vaccine studies are rhesus and cynomolgus macaques. This article provides a brief overview of the clinical picture and the pathology/pathogenesis of human filovirus infections. The current animal model options are discussed and compared with regard to their value in different applications. In general, the small animal models, in particular the mouse, are the most feasible for high biocontainment facilities and they offer the most options for research owing to the greater availability of immunologic and genetic tools. However, their mimicry of the human diseases as well as their predictive value for therapeutic efficacy in primates is limited, thereby making them, at best, valuable initial screening tools for pathophysiology, treatment and vaccine studies.

Original languageEnglish (US)
Pages (from-to)12-17
Number of pages6
JournalDMM Disease Models and Mechanisms
Volume2
Issue number1-2
DOIs
StatePublished - Jan 2009
Externally publishedYes

Fingerprint

Marburg Virus Disease
Ebola Hemorrhagic Fever
Viruses
Animals
Animal Models
Primates
Vaccines
Viral Hemorrhagic Fevers
Hemorrhagic Fever with Renal Syndrome
Central Africa
Clinical Pathology
Zoonoses
Pathology
Pathogens
Infection
Macaca mulatta
Screening
Guinea Pigs
Availability
Research

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine (miscellaneous)
  • Immunology and Microbiology (miscellaneous)
  • Neuroscience (miscellaneous)
  • Medicine(all)

Cite this

Disease modeling for Ebola and Marburg viruses. / Bente, Dennis; Gren, Jason; Strong, James E.; Feldmann, Heinz.

In: DMM Disease Models and Mechanisms, Vol. 2, No. 1-2, 01.2009, p. 12-17.

Research output: Contribution to journalArticle

Bente, Dennis ; Gren, Jason ; Strong, James E. ; Feldmann, Heinz. / Disease modeling for Ebola and Marburg viruses. In: DMM Disease Models and Mechanisms. 2009 ; Vol. 2, No. 1-2. pp. 12-17.
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