Diseases associated with altered ryanodine receptor activity

W. J. Durham, X. H.T. Wehrens, S. Sood, S. L. Hamilton

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Mutations in two intracellular Ca2+ release channels or ryanodine receptors (RyR1 and RyR2) are associated with a number of human skeletal and cardiac diseases. This chapter discusses these diseases in terms of known mechanisms, controversies, and unanswered questions. We also compare the cardiac and skeletal muscle diseases to explore common mechanisms

Original languageEnglish (US)
Pages (from-to)273-321
Number of pages49
JournalSubcellular Biochemistry
StatePublished - May 29 2007


  • And atrial fibrillation
  • And catecholaminergic polymorphic ventricular tachycardia arrhythmogenic right ventricular dysplasia type 2
  • Calcium homeostasis
  • Cardiomyopathy
  • Central core disease
  • Excitation-contraction coupling
  • Heart failure
  • Malignant hyperthermia
  • Multi-minicore disease
  • Sudden death

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology
  • Cancer Research


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