Diseases associated with altered ryanodine receptor activity

W. J. Durham, X. H.T. Wehrens, S. Sood, S. L. Hamilton

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Mutations in two intracellular Ca2+ release channels or ryanodine receptors (RyR1 and RyR2) are associated with a number of human skeletal and cardiac diseases. This chapter discusses these diseases in terms of known mechanisms, controversies, and unanswered questions.

Original languageEnglish (US)
Pages (from-to)273-321
Number of pages49
JournalSubcellular Biochemistry
StatePublished - May 29 2007
Externally publishedYes


  • And atrial fibrillation
  • And catecholaminergic polymorphic ventricular tachycardia arrhythmogenic right ventricular dysplasia type 2
  • Calcium homeostasis
  • Cardiomyopathy
  • Central core disease
  • Excitation-contraction coupling
  • Heart failure
  • Malignant hyperthermia
  • Multi-minicore disease
  • Sudden death

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology
  • Cancer Research


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