Diseases associated with altered ryanodine receptor activity

W. J. Durham; X. H.T. Wehrens; S. Sood; S. L. Hamilton

doi:10.1007/978-1-4020-6191-2_10

Diseases associated with altered ryanodine receptor activity

W. J. Durham, X. H.T. Wehrens, S. Sood, S. L. Hamilton

Internal Medicine

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Mutations in two intracellular Ca²⁺ release channels or ryanodine receptors (RyR1 and RyR2) are associated with a number of human skeletal and cardiac diseases. This chapter discusses these diseases in terms of known mechanisms, controversies, and unanswered questions. We also compare the cardiac and skeletal muscle diseases to explore common mechanisms

Original language	English (US)
Pages (from-to)	273-321
Number of pages	49
Journal	Subcellular Biochemistry
Volume	45
DOIs	https://doi.org/10.1007/978-1-4020-6191-2_10
State	Published - May 29 2007

Keywords

And atrial fibrillation
And catecholaminergic polymorphic ventricular tachycardia arrhythmogenic right ventricular dysplasia type 2
Calcium homeostasis
Cardiomyopathy
Central core disease
Excitation-contraction coupling
Heart failure
Malignant hyperthermia
Multi-minicore disease
Sudden death

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology
Cancer Research

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10.1007/978-1-4020-6191-2_10

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AU - Wehrens, X. H.T.

AU - Sood, S.

AU - Hamilton, S. L.

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AB - Mutations in two intracellular Ca2+ release channels or ryanodine receptors (RyR1 and RyR2) are associated with a number of human skeletal and cardiac diseases. This chapter discusses these diseases in terms of known mechanisms, controversies, and unanswered questions. We also compare the cardiac and skeletal muscle diseases to explore common mechanisms

KW - And atrial fibrillation

KW - And catecholaminergic polymorphic ventricular tachycardia arrhythmogenic right ventricular dysplasia type 2

KW - Calcium homeostasis

KW - Cardiomyopathy

KW - Central core disease

KW - Excitation-contraction coupling

KW - Heart failure

KW - Malignant hyperthermia

KW - Multi-minicore disease

KW - Sudden death

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JO - Subcellular Biochemistry

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ER -

Diseases associated with altered ryanodine receptor activity

Abstract

Keywords

ASJC Scopus subject areas

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