Disparities in Treatment of Patients With High-risk Prostate Cancer: Results From a Population-based Cohort

Elyn H. Wang, James B. Yu, Robert Abouassally, Neal J. Meropol, Gregory Cooper, Nilay D. Shah, Stephen B. Williams, Christopher Gonzalez, Marc C. Smaldone, Alexander Kutikov, Hui Zhu, Simon P. Kim

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Objective To assess the variation in primary treatment of high-risk prostate cancer (PCa) by different hospital characteristics in the United States. Materials and Methods We used the National Cancer Data Base to identify patients diagnosed with pretreatment high-risk PCa from 2004 to 2011. The primary outcomes were different forms of primary therapy or watchful waiting (WW) across different types of hospitals (community, comprehensive cancer community, and academic hospitals). Multivariable logistic regression analyses were used to test for differences in treatment by hospital type. Results During the study period, we identified 102,701 men diagnosed with high-risk PCa. Overall, the most common treatment was radical prostatectomy (37.0%) followed by radiation therapy (33.2%) and WW (8.5%). Compared with white men with high-risk PCa, black men had lower adjusted odds ratios (OR) for surgery at comprehensive community (OR: 0.64; P <.001) and academic (OR: 0.62; P <.001) hospitals. Similarly, black men were also more likely to be managed with WW at community (OR: 1.49; P <.001), comprehensive cancer community (OR: 1.24; P <.001), and academic (OR: 1.55; P <.001) hospitals, as well as with radiation therapy at comprehensive cancer community (OR: 1.27; P <.001) and academic hospitals (OR: 1.23; P <.001). Conclusion Disparities in the use of WW and different primary treatments among patients with high-risk PCa persisted across different types of hospitals and over time. Our findings highlight a significant racial disparity in the use of curative therapy for high-risk PCa that should be urgently addressed to ensure that all men with PCa receive appropriate care across all racial groups and cancer care facilities.

Original languageEnglish (US)
Pages (from-to)88-94
Number of pages7
StatePublished - Sep 1 2016

ASJC Scopus subject areas

  • Urology


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