Uptake, release and metabolism of norepinephrine, serotonin and γ-aminobutyric acid have been examined in slices of experimental mouse glioma and cerebrum. In contrast to brain slices, the distribution of these compounds in glioma slices fails to indicate an active concentrating mechanism. While electrical field stimulation of glioma slices did not enhance the efflux of norepinephrine-H3, evoked release of serotonin-H3 and γ-aminobutyric acid-H3 could be demonstrated. Monoamine oxidase activity in glioma was 75% of activity in brain while catechol-0-methyltransferase activity in glioma was 71% of that in brain. These findings support the contention that neuroglial tissue may modulate control of central synaptic transmission.
|Number of pages
|11 PART 1
|Published - Jun 1 1969
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
- Pharmacology, Toxicology and Pharmaceutics(all)