Disposition of neurotransmitters in experimental mouse glioma

Richard I. Katz; James S. Goodwin; Irwin J. Kopin

doi:10.1016/0024-3205(69)90017-4

Disposition of neurotransmitters in experimental mouse glioma

Richard I. Katz, James S. Goodwin, Irwin J. Kopin

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4 Scopus citations

Abstract

Uptake, release and metabolism of norepinephrine, serotonin and γ-aminobutyric acid have been examined in slices of experimental mouse glioma and cerebrum. In contrast to brain slices, the distribution of these compounds in glioma slices fails to indicate an active concentrating mechanism. While electrical field stimulation of glioma slices did not enhance the efflux of norepinephrine-H³, evoked release of serotonin-H³ and γ-aminobutyric acid-H³ could be demonstrated. Monoamine oxidase activity in glioma was 75% of activity in brain while catechol-0-methyltransferase activity in glioma was 71% of that in brain. These findings support the contention that neuroglial tissue may modulate control of central synaptic transmission.

Original language	English (US)
Pages (from-to)	561-569
Number of pages	9
Journal	Life Sciences
Volume	8
Issue number	11 PART 1
DOIs	https://doi.org/10.1016/0024-3205(69)90017-4
State	Published - Jun 1 1969
Externally published	Yes

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(69)90017-4

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title = "Disposition of neurotransmitters in experimental mouse glioma",

abstract = "Uptake, release and metabolism of norepinephrine, serotonin and γ-aminobutyric acid have been examined in slices of experimental mouse glioma and cerebrum. In contrast to brain slices, the distribution of these compounds in glioma slices fails to indicate an active concentrating mechanism. While electrical field stimulation of glioma slices did not enhance the efflux of norepinephrine-H3, evoked release of serotonin-H3 and γ-aminobutyric acid-H3 could be demonstrated. Monoamine oxidase activity in glioma was 75% of activity in brain while catechol-0-methyltransferase activity in glioma was 71% of that in brain. These findings support the contention that neuroglial tissue may modulate control of central synaptic transmission.",

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T1 - Disposition of neurotransmitters in experimental mouse glioma

AU - Katz, Richard I.

AU - Goodwin, James S.

AU - Kopin, Irwin J.

PY - 1969/6/1

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N2 - Uptake, release and metabolism of norepinephrine, serotonin and γ-aminobutyric acid have been examined in slices of experimental mouse glioma and cerebrum. In contrast to brain slices, the distribution of these compounds in glioma slices fails to indicate an active concentrating mechanism. While electrical field stimulation of glioma slices did not enhance the efflux of norepinephrine-H3, evoked release of serotonin-H3 and γ-aminobutyric acid-H3 could be demonstrated. Monoamine oxidase activity in glioma was 75% of activity in brain while catechol-0-methyltransferase activity in glioma was 71% of that in brain. These findings support the contention that neuroglial tissue may modulate control of central synaptic transmission.

AB - Uptake, release and metabolism of norepinephrine, serotonin and γ-aminobutyric acid have been examined in slices of experimental mouse glioma and cerebrum. In contrast to brain slices, the distribution of these compounds in glioma slices fails to indicate an active concentrating mechanism. While electrical field stimulation of glioma slices did not enhance the efflux of norepinephrine-H3, evoked release of serotonin-H3 and γ-aminobutyric acid-H3 could be demonstrated. Monoamine oxidase activity in glioma was 75% of activity in brain while catechol-0-methyltransferase activity in glioma was 71% of that in brain. These findings support the contention that neuroglial tissue may modulate control of central synaptic transmission.

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Disposition of neurotransmitters in experimental mouse glioma

Abstract

ASJC Scopus subject areas

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