Disposition of neurotransmitters in experimental mouse glioma

Richard I. Katz, James Goodwin, Irwin J. Kopin

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Uptake, release and metabolism of norepinephrine, serotonin and γ-aminobutyric acid have been examined in slices of experimental mouse glioma and cerebrum. In contrast to brain slices, the distribution of these compounds in glioma slices fails to indicate an active concentrating mechanism. While electrical field stimulation of glioma slices did not enhance the efflux of norepinephrine-H3, evoked release of serotonin-H3 and γ-aminobutyric acid-H3 could be demonstrated. Monoamine oxidase activity in glioma was 75% of activity in brain while catechol-0-methyltransferase activity in glioma was 71% of that in brain. These findings support the contention that neuroglial tissue may modulate control of central synaptic transmission.

Original languageEnglish (US)
Pages (from-to)561-569
Number of pages9
JournalLife Sciences
Volume8
Issue number11 PART 1
StatePublished - Jun 1 1969
Externally publishedYes

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ASJC Scopus subject areas

  • Pharmacology

Cite this

Katz, R. I., Goodwin, J., & Kopin, I. J. (1969). Disposition of neurotransmitters in experimental mouse glioma. Life Sciences, 8(11 PART 1), 561-569.