Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss

Suzhen Chen, Carlos Rio, Ru Rong Ji, Pieter Dikkes, Richard E. Coggeshall, Clifford J. Woolf, Gabriel Corfas

Research output: Contribution to journalArticle

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Abstract

Here we studied the role of signaling through ErbB-family receptors in interactions between unmyelinated axons and non-myelinating Schwann cells in adult nerves. We generated transgenic mice that postnatally express a dominant-negative ErbB receptor in non-myelinating but not in myelinating Schwann cells. These mutant mice present a progressive peripheral neuropathy characterized by extensive Schwann cell proliferation and death, loss of unmyelinated axons and marked heat and cold pain insensitivity. At later stages, C-fiber sensory neurons die by apoptosis, a process that may result from reduced GDNF (glial cell line-derived neurotrophic factor) expression in the sciatic nerve. Neuregulin 1 (NRG1)-ErbB signaling mediates, therefore, reciprocal interactions between non-myelinating Schwann cells and unmyelinated sensory neuron axons that are critical for Schwann cell and C-fiber sensory neuron survival. This study provides new insights into ErbB signaling in adult Schwann cells, the contribution of non-myelinating Schwann cells in maintaining trophic support of sensory neurons, and the possible role of disrupted ErbB signaling in peripheral sensory neuropathies.

Original languageEnglish (US)
Pages (from-to)1186-1193
Number of pages8
JournalNature Neuroscience
Volume6
Issue number11
DOIs
StatePublished - Nov 2003

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Schwann Cells
Sensory Receptor Cells
Axons
Unmyelinated Nerve Fibers
Peripheral Nervous System Diseases
Neuregulin-1
Glial Cell Line-Derived Neurotrophic Factor
Sciatic Nerve
ErbB Receptors
Transgenic Mice
Cell Death
Hot Temperature
Cell Proliferation
Apoptosis
Pain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Chen, S., Rio, C., Ji, R. R., Dikkes, P., Coggeshall, R. E., Woolf, C. J., & Corfas, G. (2003). Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss. Nature Neuroscience, 6(11), 1186-1193. https://doi.org/10.1038/nn1139

Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss. / Chen, Suzhen; Rio, Carlos; Ji, Ru Rong; Dikkes, Pieter; Coggeshall, Richard E.; Woolf, Clifford J.; Corfas, Gabriel.

In: Nature Neuroscience, Vol. 6, No. 11, 11.2003, p. 1186-1193.

Research output: Contribution to journalArticle

Chen, S, Rio, C, Ji, RR, Dikkes, P, Coggeshall, RE, Woolf, CJ & Corfas, G 2003, 'Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss', Nature Neuroscience, vol. 6, no. 11, pp. 1186-1193. https://doi.org/10.1038/nn1139
Chen, Suzhen ; Rio, Carlos ; Ji, Ru Rong ; Dikkes, Pieter ; Coggeshall, Richard E. ; Woolf, Clifford J. ; Corfas, Gabriel. / Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss. In: Nature Neuroscience. 2003 ; Vol. 6, No. 11. pp. 1186-1193.
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