Disseminated histoplasma capsulatum infection presenting as genital ulcerations

Michael B. Smith, Vicki J. Schnadig, Paul Zaharopoulos, Catherine Van Hook

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Histoplasma capsulatum infection in adults is most often subclinical but can result in disseminated disease with weight loss, fever, hepatosplenomegaly, and oropharyngeal ulcerations. Genital ulceration as the presenting sign of the disease has been reported rarely. Case: A 63-year-old woman presented with multiple vaginal ulcerations due to chronic disseminated H capsulatum infection. Initial diagnosis was made by Papanicolaou and Giemsa-stained vulvar smears. Ketoconazole therapy resulted in clearing of the lesions in 5 weeks. Conclusion: Chronic disseminated histoplasmosis is an insidious and potentially fatal disease that can present rarely as genital mucocutaneous ulcerations in women. Prompt presumptive diagnosis can be accomplished by examination of smears obtained by ulcer abrasion, permitting institution of appropriate therapy.

Original languageEnglish (US)
Pages (from-to)842-844
Number of pages3
JournalObstetrics and Gynecology
Volume89
Issue number5 II SUPPL.
DOIs
StatePublished - 1997

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Histoplasma
Infection
Histoplasmosis
Ketoconazole
Ulcer
Weight Loss
Fever
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Smith, M. B., Schnadig, V. J., Zaharopoulos, P., & Van Hook, C. (1997). Disseminated histoplasma capsulatum infection presenting as genital ulcerations. Obstetrics and Gynecology, 89(5 II SUPPL.), 842-844. https://doi.org/10.1016/S0029-7844(97)81426-3

Disseminated histoplasma capsulatum infection presenting as genital ulcerations. / Smith, Michael B.; Schnadig, Vicki J.; Zaharopoulos, Paul; Van Hook, Catherine.

In: Obstetrics and Gynecology, Vol. 89, No. 5 II SUPPL., 1997, p. 842-844.

Research output: Contribution to journalArticle

Smith, MB, Schnadig, VJ, Zaharopoulos, P & Van Hook, C 1997, 'Disseminated histoplasma capsulatum infection presenting as genital ulcerations', Obstetrics and Gynecology, vol. 89, no. 5 II SUPPL., pp. 842-844. https://doi.org/10.1016/S0029-7844(97)81426-3
Smith, Michael B. ; Schnadig, Vicki J. ; Zaharopoulos, Paul ; Van Hook, Catherine. / Disseminated histoplasma capsulatum infection presenting as genital ulcerations. In: Obstetrics and Gynecology. 1997 ; Vol. 89, No. 5 II SUPPL. pp. 842-844.
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