Disseminated mucormycosis in a patient with severe COVID-19 on venovenous extracorporeal membrane oxygenation: A case report

Hazuki Ito; Ryuichiro Kakizaki; Keisuke Harada; Daisuke Kyuno; Terufumi Kubo; Naofumi Bunya; Takehiko Kasai; Shuji Uemura; Eichi Narimatsu

doi:10.1016/j.idcr.2022.e01578

Disseminated mucormycosis in a patient with severe COVID-19 on venovenous extracorporeal membrane oxygenation: A case report

Hazuki Ito, Ryuichiro Kakizaki, Keisuke Harada, Daisuke Kyuno, Terufumi Kubo, Naofumi Bunya, Takehiko Kasai, Shuji Uemura, Eichi Narimatsu

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background: Since the global outbreak of coronavirus disease 2019 (COVID-19), there have been several reports of mucormycosis as a secondary complication. However, the disseminated type of mucormycosis is extremely rare. Case: A 58-year-old male patient with COVID-19 started receiving venovenous extracorporeal membrane oxygenation because of severe respiratory failure. During hospitalization, intra-abdominal hemorrhage occurred and an emergency laparotomy was performed. Subsequently, the patient suffered septic shock, and part of the small intestines and the abdominal wall became necrotic. Finally, the patient died. At autopsy, he was diagnosed with disseminated mucormycosis. Conclusion: Disseminated mucormycosis should be considered in patients with COVID-19 with refractory sepsis unresponsive to broad-spectrum antimicrobial therapy.

Original language	English (US)
Article number	e01578
Journal	IDCases
Volume	29
DOIs	https://doi.org/10.1016/j.idcr.2022.e01578
State	Published - Jan 2022
Externally published	Yes

Keywords

COVID-19 associated mucormycosis
Invasive fungal infection
Invasive mucormycosis
Steroid

ASJC Scopus subject areas

Infectious Diseases

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10.1016/j.idcr.2022.e01578

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@article{63b807b380e544ebac6df292c7430a10,

title = "Disseminated mucormycosis in a patient with severe COVID-19 on venovenous extracorporeal membrane oxygenation: A case report",

abstract = "Background: Since the global outbreak of coronavirus disease 2019 (COVID-19), there have been several reports of mucormycosis as a secondary complication. However, the disseminated type of mucormycosis is extremely rare. Case: A 58-year-old male patient with COVID-19 started receiving venovenous extracorporeal membrane oxygenation because of severe respiratory failure. During hospitalization, intra-abdominal hemorrhage occurred and an emergency laparotomy was performed. Subsequently, the patient suffered septic shock, and part of the small intestines and the abdominal wall became necrotic. Finally, the patient died. At autopsy, he was diagnosed with disseminated mucormycosis. Conclusion: Disseminated mucormycosis should be considered in patients with COVID-19 with refractory sepsis unresponsive to broad-spectrum antimicrobial therapy.",

keywords = "COVID-19 associated mucormycosis, Invasive fungal infection, Invasive mucormycosis, Steroid",

author = "Hazuki Ito and Ryuichiro Kakizaki and Keisuke Harada and Daisuke Kyuno and Terufumi Kubo and Naofumi Bunya and Takehiko Kasai and Shuji Uemura and Eichi Narimatsu",

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year = "2022",

month = jan,

doi = "10.1016/j.idcr.2022.e01578",

language = "English (US)",

volume = "29",

journal = "IDCases",

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T1 - Disseminated mucormycosis in a patient with severe COVID-19 on venovenous extracorporeal membrane oxygenation

T2 - A case report

AU - Ito, Hazuki

AU - Kakizaki, Ryuichiro

AU - Harada, Keisuke

AU - Kyuno, Daisuke

AU - Kubo, Terufumi

AU - Bunya, Naofumi

AU - Kasai, Takehiko

AU - Uemura, Shuji

AU - Narimatsu, Eichi

PY - 2022/1

Y1 - 2022/1

N2 - Background: Since the global outbreak of coronavirus disease 2019 (COVID-19), there have been several reports of mucormycosis as a secondary complication. However, the disseminated type of mucormycosis is extremely rare. Case: A 58-year-old male patient with COVID-19 started receiving venovenous extracorporeal membrane oxygenation because of severe respiratory failure. During hospitalization, intra-abdominal hemorrhage occurred and an emergency laparotomy was performed. Subsequently, the patient suffered septic shock, and part of the small intestines and the abdominal wall became necrotic. Finally, the patient died. At autopsy, he was diagnosed with disseminated mucormycosis. Conclusion: Disseminated mucormycosis should be considered in patients with COVID-19 with refractory sepsis unresponsive to broad-spectrum antimicrobial therapy.

AB - Background: Since the global outbreak of coronavirus disease 2019 (COVID-19), there have been several reports of mucormycosis as a secondary complication. However, the disseminated type of mucormycosis is extremely rare. Case: A 58-year-old male patient with COVID-19 started receiving venovenous extracorporeal membrane oxygenation because of severe respiratory failure. During hospitalization, intra-abdominal hemorrhage occurred and an emergency laparotomy was performed. Subsequently, the patient suffered septic shock, and part of the small intestines and the abdominal wall became necrotic. Finally, the patient died. At autopsy, he was diagnosed with disseminated mucormycosis. Conclusion: Disseminated mucormycosis should be considered in patients with COVID-19 with refractory sepsis unresponsive to broad-spectrum antimicrobial therapy.

KW - COVID-19 associated mucormycosis

KW - Invasive fungal infection

KW - Invasive mucormycosis

KW - Steroid

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U2 - 10.1016/j.idcr.2022.e01578

DO - 10.1016/j.idcr.2022.e01578

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VL - 29

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JF - IDCases

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ER -

Disseminated mucormycosis in a patient with severe COVID-19 on venovenous extracorporeal membrane oxygenation: A case report

Abstract

Keywords

ASJC Scopus subject areas

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