Distinct distribution of rare US genotypes of Kaposi's sarcoma-associated herpesvirus (KSHV) in South Texas: Implications for KSHV epidemiology

Y. J. Zhang, T. L. Davis, X. P. Wang, J. H. Deng, Jacques Baillargeon, I. T. Yeh, H. B. Jenson, S. J. Gao

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24 Scopus citations


Genotypes of Kaposi's sarcoma (KS) - associated herpesvirus (KSHV) from patients with KS in South Texas were examined. Open-reading frame (ORF) - K1 and ORF-K15 DNA segments from 16 KSHV isolates were amplified by polymerase chain reaction, and KSHV subtypes were assigned on the basis of sequence variations. K1 genotyping showed that 75% exhibited C subtype and 25% exhibited A subtype. K15 genotyping showed that 56% exhibited M form, of which 89% exhibited C3 K1 subtype and 44% exhibited P form. A unique isolate was found and was classified as C6 clade. All of the M KSHV isolates had been obtained from human immunodeficiency virus-negative classic KS patients >50 years of age, of whom 78% were Hispanic. Conversely, all KS patients with AIDS were <36 years of age and exhibited P form KSHV. These findings indicate that C3/M KSHV genotypes are more prevalent in South Texas (50%) than in other US regions (3%) and that M form KSHV likely existed in this region long before the AIDS epidemic.

Original languageEnglish (US)
Pages (from-to)125-129
Number of pages5
JournalJournal of Infectious Diseases
Issue number1
StatePublished - 2001
Externally publishedYes


ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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