Distinct distribution of rare US genotypes of Kaposi's sarcoma-associated herpesvirus (KSHV) in South Texas

Implications for KSHV epidemiology

Y. J. Zhang, T. L. Davis, X. P. Wang, J. H. Deng, Jacques Baillargeon, I. T. Yeh, H. B. Jenson, S. J. Gao

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Genotypes of Kaposi's sarcoma (KS) - associated herpesvirus (KSHV) from patients with KS in South Texas were examined. Open-reading frame (ORF) - K1 and ORF-K15 DNA segments from 16 KSHV isolates were amplified by polymerase chain reaction, and KSHV subtypes were assigned on the basis of sequence variations. K1 genotyping showed that 75% exhibited C subtype and 25% exhibited A subtype. K15 genotyping showed that 56% exhibited M form, of which 89% exhibited C3 K1 subtype and 44% exhibited P form. A unique isolate was found and was classified as C6 clade. All of the M KSHV isolates had been obtained from human immunodeficiency virus-negative classic KS patients >50 years of age, of whom 78% were Hispanic. Conversely, all KS patients with AIDS were <36 years of age and exhibited P form KSHV. These findings indicate that C3/M KSHV genotypes are more prevalent in South Texas (50%) than in other US regions (3%) and that M form KSHV likely existed in this region long before the AIDS epidemic.

Original languageEnglish (US)
Pages (from-to)125-129
Number of pages5
JournalJournal of Infectious Diseases
Volume183
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

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Human Herpesvirus 8
Epidemiology
Genotype
Kaposi's Sarcoma
Open Reading Frames
Acquired Immunodeficiency Syndrome
Hispanic Americans
HIV
Polymerase Chain Reaction
DNA

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Distinct distribution of rare US genotypes of Kaposi's sarcoma-associated herpesvirus (KSHV) in South Texas : Implications for KSHV epidemiology. / Zhang, Y. J.; Davis, T. L.; Wang, X. P.; Deng, J. H.; Baillargeon, Jacques; Yeh, I. T.; Jenson, H. B.; Gao, S. J.

In: Journal of Infectious Diseases, Vol. 183, No. 1, 2001, p. 125-129.

Research output: Contribution to journalArticle

Zhang, Y. J. ; Davis, T. L. ; Wang, X. P. ; Deng, J. H. ; Baillargeon, Jacques ; Yeh, I. T. ; Jenson, H. B. ; Gao, S. J. / Distinct distribution of rare US genotypes of Kaposi's sarcoma-associated herpesvirus (KSHV) in South Texas : Implications for KSHV epidemiology. In: Journal of Infectious Diseases. 2001 ; Vol. 183, No. 1. pp. 125-129.
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abstract = "Genotypes of Kaposi's sarcoma (KS) - associated herpesvirus (KSHV) from patients with KS in South Texas were examined. Open-reading frame (ORF) - K1 and ORF-K15 DNA segments from 16 KSHV isolates were amplified by polymerase chain reaction, and KSHV subtypes were assigned on the basis of sequence variations. K1 genotyping showed that 75{\%} exhibited C subtype and 25{\%} exhibited A subtype. K15 genotyping showed that 56{\%} exhibited M form, of which 89{\%} exhibited C3 K1 subtype and 44{\%} exhibited P form. A unique isolate was found and was classified as C6 clade. All of the M KSHV isolates had been obtained from human immunodeficiency virus-negative classic KS patients >50 years of age, of whom 78{\%} were Hispanic. Conversely, all KS patients with AIDS were <36 years of age and exhibited P form KSHV. These findings indicate that C3/M KSHV genotypes are more prevalent in South Texas (50{\%}) than in other US regions (3{\%}) and that M form KSHV likely existed in this region long before the AIDS epidemic.",
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