Distinct Inflammatory Phenotypes Are Associated With Subclinical and Clinical Cardiovascular Disease in People With Human Immunodeficiency Virus

Padraig Mcgettrick, Willard Tinago, Julie O'brien, Sarah Miles, Leo Lawler, Alejandro Garcia-Leon, Niall Mahon, John Lambert, Gerard Sheehan, Alan Landay, Caroline A. Sabin, Aoife G. Cotter, Patrick W.G. Mallon, P. Mcgettrick, E. Alvarez Barco, W. Tinago, A. Garcia-Leon, A. Mcdermott, T. Mcginty, A. G. CotterA. Macken, P. W.G. Mallon, E. Kavanagh, G. Mccarthy, G. Sheehan, J. Lambert, W. Powderly, J. Compston, C. Sabin, A. Cotter, E. Muldoon, G. Sheehan, T. Mcginty, J. S. Lambert, S. Green, K. Leamy, G. Kenny, K. Mccann, R. Mccann, C. O'broin, S. Waqas, S. Savinelli, E. Feeney, P. W.G. Mallon, A. Garcia Leon, S. Miles, D. Alalwan, R. Negi, E. De Barra, S. Mcconkey, K. Hurley, I. Sulaiman, M. Horgan, C. Sadlier, J. Eustace, C. Kelly, T. Bracken, B. Whelan, J. Low, O. Yousif, B. Mcnicholas, G. Courtney, P. Gavin

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Despite inflammation being implicated in cardiovascular disease (CVD) in people with human immunodeficiency virus (PWH), considerable heterogeneity within populations of PWH exists. Stratifying CVD risk based on inflammatory phenotype could play an important role. Using principal component analyses and unsupervised hierarchical clustering, we examined 38 biomarkers to identify inflammatory phenotypes in 2 independent cohorts of PWH. We identified 3 distinct inflammatory clusters present in both cohorts that were associated with altered risk of both subclinical CVD (cohort 1) and prevalent clinical CVD (cohort 2) after adjusting for CVD risk factors. These data support precision medicine approaches to enhance CVD risk assessment in PWH.

Original languageEnglish (US)
Pages (from-to)e616-e621
JournalJournal of Infectious Diseases
Volume230
Issue number3
DOIs
StatePublished - Sep 15 2024
Externally publishedYes

Keywords

  • CVD
  • HIV
  • inflammation
  • Inflammatory phenotypes
  • subclinical CAD

ASJC Scopus subject areas

  • General Medicine

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