Distinct routes to metastasis: Plasticity-dependent and plasticity-independent pathways

J. A. Somarelli, D. Schaeffer, M. S. Marengo, T. Bepler, D. Rouse, K. E. Ware, A. J. Hish, Y. Zhao, A. F. Buckley, J. I. Epstein, A. J. Armstrong, D. M. Virshup, Mariano Garcia-Blanco

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The cascade that culminates in macrometastases is thought to be mediated by phenotypic plasticity, including epithelial-mesenchymal and mesenchymal-epithelial transitions (EMT and MET). Although there is substantial support for the role of EMT in driving cancer cell invasion and dissemination, much less is known about the importance of MET in the later steps of metastatic colonization. We created novel reporters, which integrate transcriptional and post-transcriptional regulation, to test whether MET is required for metastasis in multiple in vivo cancer models. In a model of carcinosarcoma, metastasis occurred via an MET-dependent pathway; however, in two prostate carcinoma models, metastatic colonization was MET independent. Our results provide evidence for both MET-dependent and MET-independent metastatic pathways.

Original languageEnglish (US)
Pages (from-to)4302-4311
Number of pages10
JournalOncogene
Volume35
Issue number33
DOIs
StatePublished - Aug 18 2016

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Neoplasm Metastasis
Carcinosarcoma
Epithelial-Mesenchymal Transition
Prostate
Neoplasms
Carcinoma

ASJC Scopus subject areas

  • Medicine(all)
  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Somarelli, J. A., Schaeffer, D., Marengo, M. S., Bepler, T., Rouse, D., Ware, K. E., ... Garcia-Blanco, M. (2016). Distinct routes to metastasis: Plasticity-dependent and plasticity-independent pathways. Oncogene, 35(33), 4302-4311. https://doi.org/10.1038/onc.2015.497

Distinct routes to metastasis : Plasticity-dependent and plasticity-independent pathways. / Somarelli, J. A.; Schaeffer, D.; Marengo, M. S.; Bepler, T.; Rouse, D.; Ware, K. E.; Hish, A. J.; Zhao, Y.; Buckley, A. F.; Epstein, J. I.; Armstrong, A. J.; Virshup, D. M.; Garcia-Blanco, Mariano.

In: Oncogene, Vol. 35, No. 33, 18.08.2016, p. 4302-4311.

Research output: Contribution to journalArticle

Somarelli, JA, Schaeffer, D, Marengo, MS, Bepler, T, Rouse, D, Ware, KE, Hish, AJ, Zhao, Y, Buckley, AF, Epstein, JI, Armstrong, AJ, Virshup, DM & Garcia-Blanco, M 2016, 'Distinct routes to metastasis: Plasticity-dependent and plasticity-independent pathways', Oncogene, vol. 35, no. 33, pp. 4302-4311. https://doi.org/10.1038/onc.2015.497
Somarelli JA, Schaeffer D, Marengo MS, Bepler T, Rouse D, Ware KE et al. Distinct routes to metastasis: Plasticity-dependent and plasticity-independent pathways. Oncogene. 2016 Aug 18;35(33):4302-4311. https://doi.org/10.1038/onc.2015.497
Somarelli, J. A. ; Schaeffer, D. ; Marengo, M. S. ; Bepler, T. ; Rouse, D. ; Ware, K. E. ; Hish, A. J. ; Zhao, Y. ; Buckley, A. F. ; Epstein, J. I. ; Armstrong, A. J. ; Virshup, D. M. ; Garcia-Blanco, Mariano. / Distinct routes to metastasis : Plasticity-dependent and plasticity-independent pathways. In: Oncogene. 2016 ; Vol. 35, No. 33. pp. 4302-4311.
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