Distinguishing malignant from normal oral tissues using FTIR fiber-optic techniques

Jin Guang Wu, Yi Zhuang Xu, Cuan Wen Sun, Roger D. Soloway, Duan Fu Xu, Qi Guang Wu, Kai Hua Sun, Shi Fu Weng, Guang Xian Xu

Research output: Contribution to journalArticlepeer-review

127 Scopus citations


Oral tissue samples were studied using mid-IR fiber-optic attenuated total reflectance spectroscopy and other spectral techniques. The 1745 cm-1 band, which is assigned to the ester group (C=O) vibration of triglycerides, is a reliable marker that is present in normal tissues but absent or a weak band in malignant oral tissues. Other bands such as C-H stretching bands and the amide bands are also helpful in distinguishing malignant tissues from normal tissues. Subtraction spectra confirmed the above conclusion. In addition, Raman spectroscopic measurements were in agreement with the results observed from FTIR spectra.

Original languageEnglish (US)
Pages (from-to)185-192
Number of pages8
JournalBiopolymers - Biospectroscopy Section
Issue number4
StatePublished - 2001


  • Cancer
  • Diagnosis
  • FTIR
  • Fiber optics
  • Oral tissue

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Biomaterials
  • Organic Chemistry


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