Distinguishing malignant from normal oral tissues using FTIR fiber-optic techniques

Jin Guang Wu; Yi Zhuang Xu; Cuan Wen Sun; Roger D. Soloway; Duan Fu Xu; Qi Guang Wu; Kai Hua Sun; Shi Fu Weng; Guang Xian Xu

doi:10.1002/bip.1013

Distinguishing malignant from normal oral tissues using FTIR fiber-optic techniques

Jin Guang Wu, Yi Zhuang Xu, Cuan Wen Sun, Roger D. Soloway, Duan Fu Xu, Qi Guang Wu, Kai Hua Sun, Shi Fu Weng, Guang Xian Xu

Research output: Contribution to journal › Article › peer-review

115 Scopus citations

Abstract

Oral tissue samples were studied using mid-IR fiber-optic attenuated total reflectance spectroscopy and other spectral techniques. The 1745 cm^-1 band, which is assigned to the ester group (C=O) vibration of triglycerides, is a reliable marker that is present in normal tissues but absent or a weak band in malignant oral tissues. Other bands such as C-H stretching bands and the amide bands are also helpful in distinguishing malignant tissues from normal tissues. Subtraction spectra confirmed the above conclusion. In addition, Raman spectroscopic measurements were in agreement with the results observed from FTIR spectra.

Original language	English (US)
Pages (from-to)	185-192
Number of pages	8
Journal	Biopolymers - Biospectroscopy Section
Volume	62
Issue number	4
DOIs	https://doi.org/10.1002/bip.1013
State	Published - 2001
Externally published	Yes

Keywords

Cancer
Diagnosis
FTIR
Fiber optics
Oral tissue

ASJC Scopus subject areas

Biophysics
Biochemistry
Biomaterials
Organic Chemistry

Access to Document

10.1002/bip.1013

Cite this

@article{68f1c8d1d01047c091b6eec99bcdb8ac,

title = "Distinguishing malignant from normal oral tissues using FTIR fiber-optic techniques",

abstract = "Oral tissue samples were studied using mid-IR fiber-optic attenuated total reflectance spectroscopy and other spectral techniques. The 1745 cm-1 band, which is assigned to the ester group (C=O) vibration of triglycerides, is a reliable marker that is present in normal tissues but absent or a weak band in malignant oral tissues. Other bands such as C-H stretching bands and the amide bands are also helpful in distinguishing malignant tissues from normal tissues. Subtraction spectra confirmed the above conclusion. In addition, Raman spectroscopic measurements were in agreement with the results observed from FTIR spectra.",

keywords = "Cancer, Diagnosis, FTIR, Fiber optics, Oral tissue",

author = "Wu, {Jin Guang} and Xu, {Yi Zhuang} and Sun, {Cuan Wen} and Soloway, {Roger D.} and Xu, {Duan Fu} and Wu, {Qi Guang} and Sun, {Kai Hua} and Weng, {Shi Fu} and Xu, {Guang Xian}",

year = "2001",

doi = "10.1002/bip.1013",

language = "English (US)",

volume = "62",

pages = "185--192",

journal = "Biopolymers",

issn = "0006-3525",

publisher = "John Wiley and Sons Inc.",

number = "4",

}

TY - JOUR

T1 - Distinguishing malignant from normal oral tissues using FTIR fiber-optic techniques

AU - Wu, Jin Guang

AU - Xu, Yi Zhuang

AU - Sun, Cuan Wen

AU - Soloway, Roger D.

AU - Xu, Duan Fu

AU - Wu, Qi Guang

AU - Sun, Kai Hua

AU - Weng, Shi Fu

AU - Xu, Guang Xian

PY - 2001

Y1 - 2001

N2 - Oral tissue samples were studied using mid-IR fiber-optic attenuated total reflectance spectroscopy and other spectral techniques. The 1745 cm-1 band, which is assigned to the ester group (C=O) vibration of triglycerides, is a reliable marker that is present in normal tissues but absent or a weak band in malignant oral tissues. Other bands such as C-H stretching bands and the amide bands are also helpful in distinguishing malignant tissues from normal tissues. Subtraction spectra confirmed the above conclusion. In addition, Raman spectroscopic measurements were in agreement with the results observed from FTIR spectra.

AB - Oral tissue samples were studied using mid-IR fiber-optic attenuated total reflectance spectroscopy and other spectral techniques. The 1745 cm-1 band, which is assigned to the ester group (C=O) vibration of triglycerides, is a reliable marker that is present in normal tissues but absent or a weak band in malignant oral tissues. Other bands such as C-H stretching bands and the amide bands are also helpful in distinguishing malignant tissues from normal tissues. Subtraction spectra confirmed the above conclusion. In addition, Raman spectroscopic measurements were in agreement with the results observed from FTIR spectra.

KW - Cancer

KW - Diagnosis

KW - FTIR

KW - Fiber optics

KW - Oral tissue

UR - http://www.scopus.com/inward/record.url?scp=0034968559&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034968559&partnerID=8YFLogxK

U2 - 10.1002/bip.1013

DO - 10.1002/bip.1013

M3 - Article

C2 - 11391568

AN - SCOPUS:0034968559

VL - 62

SP - 185

EP - 192

JO - Biopolymers

JF - Biopolymers

SN - 0006-3525

IS - 4

ER -

Distinguishing malignant from normal oral tissues using FTIR fiber-optic techniques

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this