Distribution and localization of a novel cholecystokinin-releasing factor in the rat gastrointestinal tract

Nadya Tarasova, Alan W. Spannagel, Gary M. Green, Guillermo Gomez, Jason T. Reed, James C. Thompson, Mark Hellmich, Joseph R. Reeve, Rodger A. Liddle, George H. Greeley

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The purpose of this study was to examine the distribution and localization of an intestinal cholecystokinin (CCK)-releasing factor, called luminal CCK-releasing factor (LCRF), in the gastrointestinal tract and pancreas of the rat. RIA analysis indicates that LCRF immunoreactivity is found throughout the gut including the pancreas, stomach, duodenum, jejunum, ileum, and colon with the highest levels in the small intestine. Immunohistochemistry analysis shows LCRF immunoreactivity staining in intestinal villi, Brunner's glands of the duodenum, the duodenal myenteric plexus, gastric pits, pancreatic ductules, and pancreatic islets. These results indicate potential sources for secretagogue-stimulated release of luminal LCRF and support the hypothesis that LCRF is secreted into the intestinal lumen to stimulate CCK release from mucosal CCK cells.

Original languageEnglish (US)
Pages (from-to)5550-5554
Number of pages5
JournalEndocrinology
Volume138
Issue number12
StatePublished - 1997

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Cholecystokinin
Gastrointestinal Tract
Duodenum
Pancreas
Stomach
Brunner Glands
Myenteric Plexus
Jejunum
Islets of Langerhans
Ileum
Small Intestine
Colon
Immunohistochemistry
Staining and Labeling

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Tarasova, N., Spannagel, A. W., Green, G. M., Gomez, G., Reed, J. T., Thompson, J. C., ... Greeley, G. H. (1997). Distribution and localization of a novel cholecystokinin-releasing factor in the rat gastrointestinal tract. Endocrinology, 138(12), 5550-5554.

Distribution and localization of a novel cholecystokinin-releasing factor in the rat gastrointestinal tract. / Tarasova, Nadya; Spannagel, Alan W.; Green, Gary M.; Gomez, Guillermo; Reed, Jason T.; Thompson, James C.; Hellmich, Mark; Reeve, Joseph R.; Liddle, Rodger A.; Greeley, George H.

In: Endocrinology, Vol. 138, No. 12, 1997, p. 5550-5554.

Research output: Contribution to journalArticle

Tarasova, N, Spannagel, AW, Green, GM, Gomez, G, Reed, JT, Thompson, JC, Hellmich, M, Reeve, JR, Liddle, RA & Greeley, GH 1997, 'Distribution and localization of a novel cholecystokinin-releasing factor in the rat gastrointestinal tract', Endocrinology, vol. 138, no. 12, pp. 5550-5554.
Tarasova N, Spannagel AW, Green GM, Gomez G, Reed JT, Thompson JC et al. Distribution and localization of a novel cholecystokinin-releasing factor in the rat gastrointestinal tract. Endocrinology. 1997;138(12):5550-5554.
Tarasova, Nadya ; Spannagel, Alan W. ; Green, Gary M. ; Gomez, Guillermo ; Reed, Jason T. ; Thompson, James C. ; Hellmich, Mark ; Reeve, Joseph R. ; Liddle, Rodger A. ; Greeley, George H. / Distribution and localization of a novel cholecystokinin-releasing factor in the rat gastrointestinal tract. In: Endocrinology. 1997 ; Vol. 138, No. 12. pp. 5550-5554.
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