Distribution of bombesin-like peptides in the alimentary canal of several vertebrate species

George H. Greeley, Maristella Partin, Alan Spannagel, Tri Dinh, Freddie L.C. Hill, John Trowbridge, Mike Salter, Hsiao Fen Chuo, James C. Thompson

    Research output: Contribution to journalArticle

    25 Scopus citations

    Abstract

    The objective of this study was to quantitate and characterize the variants of bombesin-like immunoreactivity in the alimentary canal of the rat, rabbit, hawk, owl, dog, monkey and human. Bombesin-like immunoreactivity was found throughout the entire gastrointestinal tract of all species studied. In the rat, the highest concentration of bombesin-like immunoreactivity was found in the colon. Gel chromatography showed that bombesin-like immunoreactivity corresponded to gastrin-releasing peptide (GRP-27) and GRP-10. In the dog, the greatest concentration of bombesin-like immunoreactivity was observed in the mucosal layer of the fundus, whereas the concentration of bombesin-like immunoreactivity in the muscle layer of the dog did not vary significantly from region to region. Gel chromatography showed that bombesin-like immunoreactivity in the dog corresponded to GRP-27, bombesin, GRP-10, and a smaller fragment. In the human, the concentration of bombesin-like immunoreactivity did not vary significantly from region to region in the mucosal and muscular layers. Gel chromatography of human fundal mucosa showed that bombesin-like immunoreactivity peaks occur in the regions of GRP-27, bombesin and GRP-10. These findings substantiate the observation that bombesin-like peptides play a variety of roles in the regulation of gut function.

    Original languageEnglish (US)
    Pages (from-to)169-181
    Number of pages13
    JournalRegulatory Peptides
    Volume16
    Issue number2
    DOIs
    StatePublished - Dec 22 1986

    Keywords

    • bombesin
    • gastrin-releasing peptide
    • gut
    • vertebrates

    ASJC Scopus subject areas

    • Biochemistry
    • Physiology
    • Endocrinology
    • Clinical Biochemistry
    • Cellular and Molecular Neuroscience

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  • Cite this

    Greeley, G. H., Partin, M., Spannagel, A., Dinh, T., Hill, F. L. C., Trowbridge, J., Salter, M., Chuo, H. F., & Thompson, J. C. (1986). Distribution of bombesin-like peptides in the alimentary canal of several vertebrate species. Regulatory Peptides, 16(2), 169-181. https://doi.org/10.1016/0167-0115(86)90060-1