Distribution of bombesin-like peptides in the alimentary canal of several vertebrate species

George H. Greeley, Maristella Partin, Alan Spannagel, Tri Dinh, Freddie L C Hill, John Trowbridge, Mike Salter, Hsiao Fen Chuo, James C. Thompson

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The objective of this study was to quantitate and characterize the variants of bombesin-like immunoreactivity in the alimentary canal of the rat, rabbit, hawk, owl, dog, monkey and human. Bombesin-like immunoreactivity was found throughout the entire gastrointestinal tract of all species studied. In the rat, the highest concentration of bombesin-like immunoreactivity was found in the colon. Gel chromatography showed that bombesin-like immunoreactivity corresponded to gastrin-releasing peptide (GRP-27) and GRP-10. In the dog, the greatest concentration of bombesin-like immunoreactivity was observed in the mucosal layer of the fundus, whereas the concentration of bombesin-like immunoreactivity in the muscle layer of the dog did not vary significantly from region to region. Gel chromatography showed that bombesin-like immunoreactivity in the dog corresponded to GRP-27, bombesin, GRP-10, and a smaller fragment. In the human, the concentration of bombesin-like immunoreactivity did not vary significantly from region to region in the mucosal and muscular layers. Gel chromatography of human fundal mucosa showed that bombesin-like immunoreactivity peaks occur in the regions of GRP-27, bombesin and GRP-10. These findings substantiate the observation that bombesin-like peptides play a variety of roles in the regulation of gut function.

Original languageEnglish (US)
Pages (from-to)169-181
Number of pages13
JournalRegulatory Peptides
Volume16
Issue number2
DOIs
StatePublished - Dec 22 1986

Fingerprint

Bombesin
Canals
Vertebrates
Peptides
Chromatography
Dogs
Gel Chromatography
Gels
Rats
Hawks
Aotidae
Gastrin-Releasing Peptide
Muscle
Gastrointestinal Tract
Colon
Mucous Membrane

Keywords

  • bombesin
  • gastrin-releasing peptide
  • gut
  • vertebrates

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

Cite this

Greeley, G. H., Partin, M., Spannagel, A., Dinh, T., Hill, F. L. C., Trowbridge, J., ... Thompson, J. C. (1986). Distribution of bombesin-like peptides in the alimentary canal of several vertebrate species. Regulatory Peptides, 16(2), 169-181. https://doi.org/10.1016/0167-0115(86)90060-1

Distribution of bombesin-like peptides in the alimentary canal of several vertebrate species. / Greeley, George H.; Partin, Maristella; Spannagel, Alan; Dinh, Tri; Hill, Freddie L C; Trowbridge, John; Salter, Mike; Chuo, Hsiao Fen; Thompson, James C.

In: Regulatory Peptides, Vol. 16, No. 2, 22.12.1986, p. 169-181.

Research output: Contribution to journalArticle

Greeley, GH, Partin, M, Spannagel, A, Dinh, T, Hill, FLC, Trowbridge, J, Salter, M, Chuo, HF & Thompson, JC 1986, 'Distribution of bombesin-like peptides in the alimentary canal of several vertebrate species', Regulatory Peptides, vol. 16, no. 2, pp. 169-181. https://doi.org/10.1016/0167-0115(86)90060-1
Greeley GH, Partin M, Spannagel A, Dinh T, Hill FLC, Trowbridge J et al. Distribution of bombesin-like peptides in the alimentary canal of several vertebrate species. Regulatory Peptides. 1986 Dec 22;16(2):169-181. https://doi.org/10.1016/0167-0115(86)90060-1
Greeley, George H. ; Partin, Maristella ; Spannagel, Alan ; Dinh, Tri ; Hill, Freddie L C ; Trowbridge, John ; Salter, Mike ; Chuo, Hsiao Fen ; Thompson, James C. / Distribution of bombesin-like peptides in the alimentary canal of several vertebrate species. In: Regulatory Peptides. 1986 ; Vol. 16, No. 2. pp. 169-181.
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