Distribution of excitatory vagal fibers in canine gastric wall to control motility

E. E. Daniel, S. K. Sarna

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The distribution of cholinergic excitatory neurons in the canine gastric wall was studied by recording electrical and mechanical responses to electric stimulation of the nerves of Latarjet and close intraarterial perfusions of drugs which stimulate nerve and muscle. Electrical stimulation of the anterior nerve of Latarjet produced contractile activity on the anterior side, followed rapidly by activity on the posterior side and vice versa, indicating that the axons of the neurons from each side crossed over the other. This was not due to the propagation or conduction of electrical response activity, because electrical response activity and contractions induced locally by acetylcholine given into a small artery supplying a segment of stomach did not propagate. The cross over innervation and the direct innervation were both segmental, in that the response to nerve stimulation dropped out in segments as the branches of the nerves of Latarjet were cut successively. Mainly, preganglion axons crossed over from the anterior side to the posterior side, but both pre and postganglionic axons crossed over from the posterior side. This was demonstrated by observing the spread of electrical and mechanical responses, or lack of it, in response to local injections of acetylcholine and dimethylpeprazinium. The study shows that there is a segmental distribution of excitatory neurones in the gastric wall which is appropriate to produce a ring of contraction to control gastric emptying and mixing.

Original languageEnglish (US)
Pages (from-to)608-613
Number of pages6
JournalGastroenterology
Volume71
Issue number4
StatePublished - 1976
Externally publishedYes

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Axons
Canidae
Stomach
Electric Stimulation
Acetylcholine
Neurons
Cholinergic Neurons
Gastric Emptying
Arteries
Perfusion
Muscles
Injections
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Distribution of excitatory vagal fibers in canine gastric wall to control motility. / Daniel, E. E.; Sarna, S. K.

In: Gastroenterology, Vol. 71, No. 4, 1976, p. 608-613.

Research output: Contribution to journalArticle

Daniel, E. E. ; Sarna, S. K. / Distribution of excitatory vagal fibers in canine gastric wall to control motility. In: Gastroenterology. 1976 ; Vol. 71, No. 4. pp. 608-613.
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