Distribution of neurotensin in the canine gastrointestinal tract

H. Doyle, G. H. Greeley, L. Mate, T. Sakamoto, Courtney Townsend, J. C. Thompson

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The distribution of immunoreactive neurotensin in the canine gastrointestinal tract from the esophagus to the rectum, as well as in the pancreas, was determined by a specific neurotensin radioimmunoassay. Immunoreactive neurotensin was found throughout the gastrointestinal tract and in the pancreas. The highest concentrations of immunoreactive neurotensin were found in the mucosal extracts of the jenunum (422 ± 68 ng/gm) and ileum (3025 ± 289 ng/gm). Small but substantial amounts of immunoreactive neurotensin were found in the esophagus, fundus (includes fundus and corpus), antrum, duodenum, colon, and pancreas. The concentrations of neurotensin in the mucosal extracts of the jejunum and ileum increased in a graded fashion from the proximal jejunum to the distal ileum. The neurotensin concentration in extracts of the seromuscular layers of jejunum (73 ± 14 ng/gm) and ileum (187 ± 38 ng/gm) were statistically higher in comparison with other gut loci.

Original languageEnglish
Pages (from-to)337-341
Number of pages5
JournalSurgery
Volume97
Issue number3
StatePublished - 1985
Externally publishedYes

Fingerprint

Neurotensin
Gastrointestinal Tract
Canidae
Ileum
Jejunum
Pancreas
Esophagus
Duodenum
Rectum
Radioimmunoassay
Colon

ASJC Scopus subject areas

  • Surgery

Cite this

Doyle, H., Greeley, G. H., Mate, L., Sakamoto, T., Townsend, C., & Thompson, J. C. (1985). Distribution of neurotensin in the canine gastrointestinal tract. Surgery, 97(3), 337-341.

Distribution of neurotensin in the canine gastrointestinal tract. / Doyle, H.; Greeley, G. H.; Mate, L.; Sakamoto, T.; Townsend, Courtney; Thompson, J. C.

In: Surgery, Vol. 97, No. 3, 1985, p. 337-341.

Research output: Contribution to journalArticle

Doyle, H, Greeley, GH, Mate, L, Sakamoto, T, Townsend, C & Thompson, JC 1985, 'Distribution of neurotensin in the canine gastrointestinal tract', Surgery, vol. 97, no. 3, pp. 337-341.
Doyle H, Greeley GH, Mate L, Sakamoto T, Townsend C, Thompson JC. Distribution of neurotensin in the canine gastrointestinal tract. Surgery. 1985;97(3):337-341.
Doyle, H. ; Greeley, G. H. ; Mate, L. ; Sakamoto, T. ; Townsend, Courtney ; Thompson, J. C. / Distribution of neurotensin in the canine gastrointestinal tract. In: Surgery. 1985 ; Vol. 97, No. 3. pp. 337-341.
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