Distribution of the growth associated protein GAP-43 in the central processes of axotomized primary afferents in the adult rat spinal cord; presence of growth cone-like structures

R. E. Coggeshall, M. L. Reynolds, C. J. Woolf

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

GAP-43-immunolabelled structures were visualized by electron microscopy in the adult rat L4-L5 superficial dorsal horn 2 weeks after sciatic nerve transection. The majority of immunolabelled elements were unmyelinated axons, but some synaptic terminals and myelinated axons also labelled. The labelled unmyelinated axons were commonly located in prominent bundles which on serial section analysis could be followed into larger single trunks. These enlargements contain many organelles and give rise to smaller processes, which is compatible with their being growth cones. Sciatic nerve transection may result, therefore, in central regenerative processes which reorganize the neuropil and contribute to the decreased sensibility and pain that follows peripheral nerve section.

Original languageEnglish (US)
Pages (from-to)37-41
Number of pages5
JournalNeuroscience Letters
Volume131
Issue number1
DOIs
StatePublished - Sep 30 1991

Keywords

  • Dorsal horn
  • Electron microscopy
  • Nerve injury
  • Pain
  • Regeneration
  • Synaptogenesis

ASJC Scopus subject areas

  • Neuroscience(all)

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