Distribution of the inositol trisphosphate receptor in the catfish retina

Maria Micci, B. N. Christensen

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Inositol 1,4,5-trisphosphate (InsP3) mobilizes intracellular stored Ca2+ by binding to specific receptors that are similar to the ryanodine receptor of skeletal and cardiac muscle. We have immunolocalized the InsP3 receptor to the inner nuclear layer and limiting membranes of the catfish retina. Immunocytochemistry on dissociated retinal cells further localized the receptor in the horizontal, bipolar and Muller glial cells. Immunostaining of the rat retina localized the InsP3 receptor to the plexiform layers. These data show a different distribution of InsP3 receptor in the catfish retina compared to that of other vertebrates, that may be suggestive of a different functional role for this receptor in different species.

Original languageEnglish (US)
Pages (from-to)139-147
Number of pages9
JournalBrain Research
Volume720
Issue number1-2
DOIs
StatePublished - May 13 1996

Fingerprint

Catfishes
Inositol
Retina
Ependymoglial Cells
Ryanodine Receptor Calcium Release Channel
Inositol 1,4,5-Trisphosphate
Neuroglia
Vertebrates
Myocardium
Skeletal Muscle
Immunohistochemistry
Membranes

Keywords

  • Calcium
  • Calcium channel
  • Immunoblotting
  • Immunochemistry
  • Neural pathway
  • Retina

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Distribution of the inositol trisphosphate receptor in the catfish retina. / Micci, Maria; Christensen, B. N.

In: Brain Research, Vol. 720, No. 1-2, 13.05.1996, p. 139-147.

Research output: Contribution to journalArticle

Micci, Maria ; Christensen, B. N. / Distribution of the inositol trisphosphate receptor in the catfish retina. In: Brain Research. 1996 ; Vol. 720, No. 1-2. pp. 139-147.
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