Distribution of the inositol trisphosphate receptor in the catfish retina

M. A. Micci, B. N. Christensen

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Inositol 1,4,5-trisphosphate (InsP3) mobilizes intracellular stored Ca2+ by binding to specific receptors that are similar to the ryanodine receptor of skeletal and cardiac muscle. We have immunolocalized the InsP3 receptor to the inner nuclear layer and limiting membranes of the catfish retina. Immunocytochemistry on dissociated retinal cells further localized the receptor in the horizontal, bipolar and Muller glial cells. Immunostaining of the rat retina localized the InsP3 receptor to the plexiform layers. These data show a different distribution of InsP3 receptor in the catfish retina compared to that of other vertebrates, that may be suggestive of a different functional role for this receptor in different species.

Original languageEnglish (US)
Pages (from-to)139-147
Number of pages9
JournalBrain Research
Volume720
Issue number1-2
DOIs
StatePublished - May 13 1996

Keywords

  • Calcium
  • Calcium channel
  • Immunoblotting
  • Immunochemistry
  • Neural pathway
  • Retina

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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