Distributions of V/Q heterogeneity during broncho-constriction measured with pet: Contribution of sub-resolution heterogeneity to gas exchange impairment

M. Vidal-Melo; D. Layfield; R. S. Harris; J. G. Venegas

Distributions of V/Q heterogeneity during broncho-constriction measured with pet: Contribution of sub-resolution heterogeneity to gas exchange impairment

M. Vidal-Melo, D. Layfield, R. S. Harris, J. G. Venegas

Research output: Contribution to journal › Conference article › peer-review

Abstract

Positron emission tomography (PET) imaging of i.v. injected ¹³N-labeled saline was used to quantify V/Q heterogeneity and estimate arterial blood gases in methacholine bronchoconstricted sheep. Imaging data were analyzed assuming a uniform V/Q distribution within the resolution elements, and assuming a double compartment model of sub-resolution heterogeneity. Results indicate that V/Q heterogeneity is present within volumes smaller than a spatial resolution of 2.2 cm³ and that such heterogeneity is responsible for approximately 30% of the total alveolar-arterial O₂ and CO₂ gradients. Tracer kinetics analysis of PET images provides a quantitative assessment of global V/Q heterogeneity including that corresponding to length scales smaller than the spatial resolution of the imaging method.

Original language	English (US)
Pages (from-to)	1495-1496
Number of pages	2
Journal	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	2
State	Published - 2002
Externally published	Yes
Event	Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States Duration: Oct 23 2002 → Oct 26 2002

Keywords

Functional imaging
Heterogeneity
Perfusion
PET
Pulmonary gas exchange
Ventilation

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

Cite this

Distributions of V/Q heterogeneity during broncho-constriction measured with pet: Contribution of sub-resolution heterogeneity to gas exchange impairment. / Vidal-Melo, M.; Layfield, D.; Harris, R. S. et al.
In: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, Vol. 2, 2002, p. 1495-1496.

Research output: Contribution to journal › Conference article › peer-review

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title = "Distributions of V/Q heterogeneity during broncho-constriction measured with pet: Contribution of sub-resolution heterogeneity to gas exchange impairment",

abstract = "Positron emission tomography (PET) imaging of i.v. injected 13N-labeled saline was used to quantify V/Q heterogeneity and estimate arterial blood gases in methacholine bronchoconstricted sheep. Imaging data were analyzed assuming a uniform V/Q distribution within the resolution elements, and assuming a double compartment model of sub-resolution heterogeneity. Results indicate that V/Q heterogeneity is present within volumes smaller than a spatial resolution of 2.2 cm3 and that such heterogeneity is responsible for approximately 30% of the total alveolar-arterial O2 and CO2 gradients. Tracer kinetics analysis of PET images provides a quantitative assessment of global V/Q heterogeneity including that corresponding to length scales smaller than the spatial resolution of the imaging method.",

keywords = "Functional imaging, Heterogeneity, Perfusion, PET, Pulmonary gas exchange, Ventilation",

author = "M. Vidal-Melo and D. Layfield and Harris, {R. S.} and Venegas, {J. G.}",

year = "2002",

language = "English (US)",

volume = "2",

pages = "1495--1496",

journal = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",

issn = "0589-1019",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

note = "Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) ; Conference date: 23-10-2002 Through 26-10-2002",

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TY - JOUR

T1 - Distributions of V/Q heterogeneity during broncho-constriction measured with pet

T2 - Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS)

AU - Vidal-Melo, M.

AU - Layfield, D.

AU - Harris, R. S.

AU - Venegas, J. G.

PY - 2002

Y1 - 2002

N2 - Positron emission tomography (PET) imaging of i.v. injected 13N-labeled saline was used to quantify V/Q heterogeneity and estimate arterial blood gases in methacholine bronchoconstricted sheep. Imaging data were analyzed assuming a uniform V/Q distribution within the resolution elements, and assuming a double compartment model of sub-resolution heterogeneity. Results indicate that V/Q heterogeneity is present within volumes smaller than a spatial resolution of 2.2 cm3 and that such heterogeneity is responsible for approximately 30% of the total alveolar-arterial O2 and CO2 gradients. Tracer kinetics analysis of PET images provides a quantitative assessment of global V/Q heterogeneity including that corresponding to length scales smaller than the spatial resolution of the imaging method.

AB - Positron emission tomography (PET) imaging of i.v. injected 13N-labeled saline was used to quantify V/Q heterogeneity and estimate arterial blood gases in methacholine bronchoconstricted sheep. Imaging data were analyzed assuming a uniform V/Q distribution within the resolution elements, and assuming a double compartment model of sub-resolution heterogeneity. Results indicate that V/Q heterogeneity is present within volumes smaller than a spatial resolution of 2.2 cm3 and that such heterogeneity is responsible for approximately 30% of the total alveolar-arterial O2 and CO2 gradients. Tracer kinetics analysis of PET images provides a quantitative assessment of global V/Q heterogeneity including that corresponding to length scales smaller than the spatial resolution of the imaging method.

KW - Functional imaging

KW - Heterogeneity

KW - Perfusion

KW - PET

KW - Pulmonary gas exchange

KW - Ventilation

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AN - SCOPUS:0036906937

SN - 0589-1019

VL - 2

SP - 1495

EP - 1496

JO - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

JF - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

Y2 - 23 October 2002 through 26 October 2002

ER -

Distributions of V/Q heterogeneity during broncho-constriction measured with pet: Contribution of sub-resolution heterogeneity to gas exchange impairment

Abstract

Keywords

ASJC Scopus subject areas

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