Diuretic-induced hypokalaemia and ventricular arrhythmias

O. B. Holland

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In the past, adverse cardiac effect of potassium depletion in non-digitalised patients and in patients without cardiac disease were considered to be minimal. However, several studies have now demonstrated a significant incidence of ventricular ectopic activity in diuretic-treated patients, particularly in those who became hypokalaemic. Potassium repletion with potassium-sparing diuretics or with potassium chloride supplementation has generally demonstrated a beneficial therapeutic effect in reducing ventricular ectopic activity. However, occasional patients may have persistent ventricular ectopic activity after diuretic therapy which may result from focal myocardial lesions associated with potassium depletion. In addition, factors other than potassium depletion appear to initiate or magnify diuretic-induced ventricular ectopic activity. Thus, to avoid these adverse cardiac effects, normokalaemia should be maintained during long term diuretic therapy.

Original languageEnglish (US)
Pages (from-to)86-92
Number of pages7
JournalDrugs
Volume28
Issue numberSUPPL. 1
StatePublished - 1984

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Hypokalemia
Diuretics
Cardiac Arrhythmias
Potassium
Potassium Sparing Diuretics
Potassium Chloride
Therapeutic Uses
Heart Diseases
Incidence
Therapeutics

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Toxicology

Cite this

Holland, O. B. (1984). Diuretic-induced hypokalaemia and ventricular arrhythmias. Drugs, 28(SUPPL. 1), 86-92.

Diuretic-induced hypokalaemia and ventricular arrhythmias. / Holland, O. B.

In: Drugs, Vol. 28, No. SUPPL. 1, 1984, p. 86-92.

Research output: Contribution to journalArticle

Holland, OB 1984, 'Diuretic-induced hypokalaemia and ventricular arrhythmias', Drugs, vol. 28, no. SUPPL. 1, pp. 86-92.
Holland, O. B. / Diuretic-induced hypokalaemia and ventricular arrhythmias. In: Drugs. 1984 ; Vol. 28, No. SUPPL. 1. pp. 86-92.
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