Diverse Clinical Manifestations and Challenges of Mucormycosis: Insights From Serial Cases

Marisa C. Nielsen, Filipe M. Cerqueira, Sri Bharathi Kavuri, Caitlin M. Raymond, Aeman Muneeb, Andrzej S. Kudlicki, Shafaq Tariq, Mingru Liu, Andrew L. Routh, Suimin Qiu, Ping Ren

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Mucormycosis is a severe and potentially life-threatening infection caused by a group of fungi classified as mucormycetes within the scientific order Mucorales. These infections are characterized by rapid and invasive fungal growth, presenting significant treatment challenges. Here we present 5 cases encountered from 2018 to 2022 at the University of Texas Medical Branch in Galveston, Texas, including a novel Apophysomyces species. These cases illustrate the diverse clinical manifestations of mucormycosis, including pulmonary, rhino-cerebral, gastrointestinal, and soft tissue involvement. Our investigation incorporates information provided by a multidisciplinary team of clinical collaborators, emphasizing the findings from radiology, histopathology, and microbiology. Given the escalating global incidence of mucormycosis, it is crucial for clinicians to become familiar with associated clinical findings, comorbidities, and risk factors to facilitate prompt recognition, appropriate diagnostic testing, and timely initiation of treatment.

Original languageEnglish (US)
Article numberofad527
JournalOpen Forum Infectious Diseases
Volume10
Issue number11
DOIs
StatePublished - Nov 1 2023
Externally publishedYes

Keywords

  • Apophysomyces
  • clinical mycology
  • fungal infections
  • mucormycetes
  • mucormycosis

ASJC Scopus subject areas

  • Oncology
  • Infectious Diseases

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