Diversity-oriented synthesis of natural product-like libraries

Gang Liu, Yulin Li, Fajun Nan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Natural products provide the most important sources of lead compounds in drug discovery. With the development of high-throughput screening (HTS) technology and in depth studies in chemical biology, exploring pharmaceutically relevant chemical space of natural products is vital. Employing diversity-oriented synthesis (DOS) to construct skeletally complex natural product-like libraries and using it in the studies of chemical biology and lead discovery is becoming a tendency. The development of exceptionally efficient, stereoselective, and chemoselective reactions that can be applied to a wide range of substrates play key roles.

Original languageEnglish (US)
Pages (from-to)734-742
Number of pages9
JournalProgress in Chemistry
Volume18
Issue number6
StatePublished - Jun 1 2006
Externally publishedYes

Fingerprint

Biological Products
Lead compounds
Screening
Throughput
Substrates

Keywords

  • Diversity-oriented synthesis (DOS)
  • Natural product-like libraries
  • Target-oriented synthesis

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Diversity-oriented synthesis of natural product-like libraries. / Liu, Gang; Li, Yulin; Nan, Fajun.

In: Progress in Chemistry, Vol. 18, No. 6, 01.06.2006, p. 734-742.

Research output: Contribution to journalArticle

Liu, Gang ; Li, Yulin ; Nan, Fajun. / Diversity-oriented synthesis of natural product-like libraries. In: Progress in Chemistry. 2006 ; Vol. 18, No. 6. pp. 734-742.
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