DNA-associated click chemistry

Mohammad Mojibul Haque, Xiaohua Peng

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


This review highlights the most recent advances in click chemistry associated with DNA. Cu[I]-catalyzed azides-alkynes Huisgen cycloadditions (CuAAC) and a strain-promoted alkyne-azide cycloaddition (SPAAC) are two popular click reactions that have great impact in DNA science. The simplicity, versatility, orthogonality, and high efficiency of click reaction along with a stable triazole product have been instrumental for the successful application of this reaction in the field of nucleic acid chemistry. CuAAC and SPAAC reactions have been widely used for DNA modification, including DNA labeling, metallization, conjugation, cross-linking, and ligation. Modified oligodeoxynucleotides obtained from click reaction have been extensively applied in the fields of drug discovery, nanotechnology, bio-conjugation, and material sciences, among others. The most recent advances in the synthesis and applications of clickable DNAs are discussed in detail in this article.

Original languageEnglish (US)
Pages (from-to)215-231
Number of pages17
JournalScience China Chemistry
Issue number2
StatePublished - Feb 2014
Externally publishedYes


  • "click" chemistry
  • DNA functionalization
  • DNA ligation and cross-linking
  • oligodeoxynucleotides

ASJC Scopus subject areas

  • General Chemistry


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