DNA damage induced by peroxynitrite: Subsequent biological effects

Csaba Szabo, Hiroshi Ohshima

Research output: Contribution to journalArticle

359 Scopus citations

Abstract

Nitric oxide (NO) and superoxide rapidly react to yield peroxynitrite. Peroxynitrite is a potent oxidant which reacts with proteins, lipids, and DNA. The present paper overviews the various DNA modifications induced by exposure to peroxynitrite or NO and superoxide concurrently, with special reference to the formation of 8-nitroguanine and 8-oxoguanine as well as the induction of DNA single strand breakage. In addition, we review the secondary processes that may follow the process of DNA damage, such as activation of the nuclear enzyme, poly(ADP-ribose) synthetase, apoptosis, and carcinogenesis.

Original languageEnglish (US)
Pages (from-to)373-385
Number of pages13
JournalNitric Oxide - Biology and Chemistry
Volume1
Issue number5
DOIs
StatePublished - 1997
Externally publishedYes

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Keywords

  • 8- oxoguanine
  • 8-nitroguanine
  • Apoptosis
  • Cancer
  • Diabetes
  • DNA strand break
  • Endotoxin
  • Free radical
  • Inflammation
  • Nitric oxide
  • Peroxynitrite
  • Poly(ADP-ribose) synthetase
  • Septic shock
  • Stroke
  • Superoxide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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