DNA damage induced by peroxynitrite: Subsequent biological effects

Csaba Szabó, Hiroshi Ohshima

    Research output: Contribution to journalReview articlepeer-review

    365 Scopus citations

    Abstract

    Nitric oxide (NO) and superoxide rapidly react to yield peroxynitrite. Peroxynitrite is a potent oxidant which reacts with proteins, lipids, and DNA. The present paper overviews the various DNA modifications induced by exposure to peroxynitrite or NO and superoxide concurrently, with special reference to the formation of 8-nitroguanine and 8-oxoguanine as well as the induction of DNA single strand breakage. In addition, we review the secondary processes that may follow the process of DNA damage, such as activation of the nuclear enzyme, poly(ADP-ribose) synthetase, apoptosis, and carcinogenesis.

    Original languageEnglish (US)
    Pages (from-to)373-385
    Number of pages13
    JournalNitric Oxide - Biology and Chemistry
    Volume1
    Issue number5
    DOIs
    StatePublished - Oct 1997

    Keywords

    • 8- oxoguanine
    • 8-nitroguanine
    • Apoptosis
    • Cancer
    • DNA strand break
    • Diabetes
    • Endotoxin
    • Free radical
    • Inflammation
    • Nitric oxide
    • Peroxynitrite
    • Poly(ADP-ribose) synthetase
    • Septic shock
    • Stroke
    • Superoxide

    ASJC Scopus subject areas

    • Biochemistry
    • Physiology
    • Clinical Biochemistry
    • Cancer Research

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