DNA hypomethylation in Morris hepatomas

Leejane Lu, Erika Randerath, Kurt Randerath

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29 Scopus citations

Abstract

The 5-methylcytosine (m5C) content of DNAs from Morris hepatomas of varying growth rates and from normal liver was analyzed. DNA methylation in all hepatomas studied was found to be 20-45% less than in normal liver. This result was confirmed independently by restriction endonuclease (Hpa II and Msp I) analysis. While these results agreed with recent literature data suggesting hypomethylation of DNA from some neoplastic sources, no correlation was observed between the extent of DNA hypomethylation and the growth rates of the tumors.

Original languageEnglish
Pages (from-to)231-239
Number of pages9
JournalCancer Letters
Volume19
Issue number2
DOIs
StatePublished - 1983
Externally publishedYes

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ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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