TY - JOUR
T1 - DNA methylation clock DNAmFitAge shows regular exercise is associated with slower aging and systemic adaptation
AU - Jokai, Matyas
AU - Torma, Ferenc
AU - McGreevy, Kristen M.
AU - Koltai, Erika
AU - Bori, Zoltan
AU - Babszki, Gergely
AU - Bakonyi, Peter
AU - Gombos, Zoltan
AU - Gyorgy, Bernadett
AU - Aczel, Dora
AU - Toth, Laszlo
AU - Osvath, Peter
AU - Fridvalszky, Marcell
AU - Teglas, Timea
AU - Posa, Aniko
AU - Kujach, Sylwester
AU - Olek, Robert
AU - Kawamura, Takuji
AU - Seki, Yasuhiro
AU - Suzuki, Katsuhiko
AU - Tanisawa, Kumpei
AU - Goto, Sataro
AU - Kerepesi, Csaba
AU - Boldogh, Istvan
AU - Ba, Xueqing
AU - Davies, Kelvin J.A.
AU - Horvath, Steve
AU - Radak, Zsolt
N1 - Funding Information:
Open access funding provided by Hungarian University of Sports Science. Z. R., F. T., and M. J. were provided support by the National Excellence Program (126823) and the Scientific Excellence Program, TKP2020-NKA-17, TKP2021-EGA-37 at the Hungarian University Sport Science, Innovation and Technology Ministry, Hungary. S. H., K. M. M., and A. T. L. received support from 1U01AG060908. K. J. A. D. was supported by grant #ES003598 from the National Institute of Environmental Health Sciences of the US National Institutes of Health and by grant #AG052374 from the National Institute on Aging of the US National Institutes of Health.
Publisher Copyright:
© 2023, The Author(s).
PY - 2023
Y1 - 2023
N2 - DNAmPhenoAge, DNAmGrimAge, and the newly developed DNAmFitAge are DNA methylation (DNAm)-based biomarkers that reflect the individual aging process. Here, we examine the relationship between physical fitness and DNAm-based biomarkers in adults aged 33–88 with a wide range of physical fitness (including athletes with long-term training history). Higher levels of VO2max (ρ = 0.2, p = 6.4E − 4, r = 0.19, p = 1.2E − 3), Jumpmax (p = 0.11, p = 5.5E − 2, r = 0.13, p = 2.8E − 2), Gripmax (ρ = 0.17, p = 3.5E − 3, r = 0.16, p = 5.6E − 3), and HDL levels (ρ = 0.18, p = 1.95E − 3, r = 0.19, p = 1.1E − 3) are associated with better verbal short-term memory. In addition, verbal short-term memory is associated with decelerated aging assessed with the new DNAm biomarker FitAgeAcceleration (ρ: − 0.18, p = 0.0017). DNAmFitAge can distinguish high-fitness individuals from low/medium-fitness individuals better than existing DNAm biomarkers and estimates a younger biological age in the high-fit males and females (1.5 and 2.0 years younger, respectively). Our research shows that regular physical exercise contributes to observable physiological and methylation differences which are beneficial to the aging process. DNAmFitAge has now emerged as a new biological marker of quality of life.
AB - DNAmPhenoAge, DNAmGrimAge, and the newly developed DNAmFitAge are DNA methylation (DNAm)-based biomarkers that reflect the individual aging process. Here, we examine the relationship between physical fitness and DNAm-based biomarkers in adults aged 33–88 with a wide range of physical fitness (including athletes with long-term training history). Higher levels of VO2max (ρ = 0.2, p = 6.4E − 4, r = 0.19, p = 1.2E − 3), Jumpmax (p = 0.11, p = 5.5E − 2, r = 0.13, p = 2.8E − 2), Gripmax (ρ = 0.17, p = 3.5E − 3, r = 0.16, p = 5.6E − 3), and HDL levels (ρ = 0.18, p = 1.95E − 3, r = 0.19, p = 1.1E − 3) are associated with better verbal short-term memory. In addition, verbal short-term memory is associated with decelerated aging assessed with the new DNAm biomarker FitAgeAcceleration (ρ: − 0.18, p = 0.0017). DNAmFitAge can distinguish high-fitness individuals from low/medium-fitness individuals better than existing DNAm biomarkers and estimates a younger biological age in the high-fit males and females (1.5 and 2.0 years younger, respectively). Our research shows that regular physical exercise contributes to observable physiological and methylation differences which are beneficial to the aging process. DNAmFitAge has now emerged as a new biological marker of quality of life.
KW - DNA methylation
KW - DNAmFitAge
KW - Regular exercise
KW - Slower aging
KW - Systemic adaptation
UR - http://www.scopus.com/inward/record.url?scp=85159722620&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85159722620&partnerID=8YFLogxK
U2 - 10.1007/s11357-023-00826-1
DO - 10.1007/s11357-023-00826-1
M3 - Article
C2 - 37209203
AN - SCOPUS:85159722620
SN - 2509-2715
JO - GeroScience
JF - GeroScience
ER -