Do omega-3 polyunsaturated fatty acids reduce risk of sudden cardiac death and ventricular arrhythmias? A meta-analysis of randomized trials

Georges Khoueiry, Nidal Abi Rafeh, Erinmarie Sullivan, Faisal Saiful, Zehra Jaffery, David N. Kenigsberg, Subramaniam C. Krishnan, Sanjaya Khanal, Soad Bekheit, Marcin Kowalski

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Introduction: Omega-3 polyunsaturated fatty acids (PUFA) have demonstrated to have antiarrhythmic properties. However, randomized studies have shown inconsistent results. Objective: We aimed to analyze the effect of omega-3 PUFA on preventing potentially fatal ventricular arrhythmias and sudden cardiac death. Methods: Randomized trials comparing omega-3 PUFA to placebo and reporting sudden cardiac death (SCD) or first implanted cardioverter-defibrillator (ICD) event for ventricular tachycardia or fibrillation were included in this study. A meta-analysis using a random effects model was performed and results were expressed in terms of Odds Ratio (OR) and 95% Confidence Interval (CI) after evaluating for interstudy heterogeneity using I2. The reported data were extracted on the basis of the intention-to-treat principle. Results: A total of 32,919 patients were included in nine trials; 16,465 patients received omega-3 PUFA and 16,454 received placebo. When comparing omega-3 PUFA to placebo, there was nonsignificant risk reduction of SCD or ventricular arrhythmias (OR=0.82 [95% CI: 0.60-1.21], p=0.21 I2=49.7%). Conclusion: Dietary supplementation with omega-3 PUFA does not affect the risk of SCD or ventricular arrhythmias.

Original languageEnglish (US)
Pages (from-to)251-256
Number of pages6
JournalHeart and Lung: Journal of Acute and Critical Care
Volume42
Issue number4
DOIs
StatePublished - Jul 2013
Externally publishedYes

Fingerprint

Sudden Cardiac Death
Omega-3 Fatty Acids
Unsaturated Fatty Acids
Meta-Analysis
Cardiac Arrhythmias
Placebos
Odds Ratio
Confidence Intervals
Defibrillators
Ventricular Fibrillation
Risk Reduction Behavior
Ventricular Tachycardia
Dietary Supplements

Keywords

  • Arrhythmias
  • Dietary supplements
  • Fish oil
  • Sudden cardiac death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Critical Care and Intensive Care Medicine
  • Pulmonary and Respiratory Medicine

Cite this

Do omega-3 polyunsaturated fatty acids reduce risk of sudden cardiac death and ventricular arrhythmias? A meta-analysis of randomized trials. / Khoueiry, Georges; Abi Rafeh, Nidal; Sullivan, Erinmarie; Saiful, Faisal; Jaffery, Zehra; Kenigsberg, David N.; Krishnan, Subramaniam C.; Khanal, Sanjaya; Bekheit, Soad; Kowalski, Marcin.

In: Heart and Lung: Journal of Acute and Critical Care, Vol. 42, No. 4, 07.2013, p. 251-256.

Research output: Contribution to journalArticle

Khoueiry, G, Abi Rafeh, N, Sullivan, E, Saiful, F, Jaffery, Z, Kenigsberg, DN, Krishnan, SC, Khanal, S, Bekheit, S & Kowalski, M 2013, 'Do omega-3 polyunsaturated fatty acids reduce risk of sudden cardiac death and ventricular arrhythmias? A meta-analysis of randomized trials', Heart and Lung: Journal of Acute and Critical Care, vol. 42, no. 4, pp. 251-256. https://doi.org/10.1016/j.hrtlng.2013.03.006
Khoueiry, Georges ; Abi Rafeh, Nidal ; Sullivan, Erinmarie ; Saiful, Faisal ; Jaffery, Zehra ; Kenigsberg, David N. ; Krishnan, Subramaniam C. ; Khanal, Sanjaya ; Bekheit, Soad ; Kowalski, Marcin. / Do omega-3 polyunsaturated fatty acids reduce risk of sudden cardiac death and ventricular arrhythmias? A meta-analysis of randomized trials. In: Heart and Lung: Journal of Acute and Critical Care. 2013 ; Vol. 42, No. 4. pp. 251-256.
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