Do omega-3 polyunsaturated fatty acids reduce risk of sudden cardiac death and ventricular arrhythmias? A meta-analysis of randomized trials

Georges Khoueiry, Nidal Abi Rafeh, Erinmarie Sullivan, Faisal Saiful, Zehra Jaffery, David N. Kenigsberg, Subramaniam C. Krishnan, Sanjaya Khanal, Soad Bekheit, Marcin Kowalski

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Introduction: Omega-3 polyunsaturated fatty acids (PUFA) have demonstrated to have antiarrhythmic properties. However, randomized studies have shown inconsistent results. Objective: We aimed to analyze the effect of omega-3 PUFA on preventing potentially fatal ventricular arrhythmias and sudden cardiac death. Methods: Randomized trials comparing omega-3 PUFA to placebo and reporting sudden cardiac death (SCD) or first implanted cardioverter-defibrillator (ICD) event for ventricular tachycardia or fibrillation were included in this study. A meta-analysis using a random effects model was performed and results were expressed in terms of Odds Ratio (OR) and 95% Confidence Interval (CI) after evaluating for interstudy heterogeneity using I2. The reported data were extracted on the basis of the intention-to-treat principle. Results: A total of 32,919 patients were included in nine trials; 16,465 patients received omega-3 PUFA and 16,454 received placebo. When comparing omega-3 PUFA to placebo, there was nonsignificant risk reduction of SCD or ventricular arrhythmias (OR=0.82 [95% CI: 0.60-1.21], p=0.21 I2=49.7%). Conclusion: Dietary supplementation with omega-3 PUFA does not affect the risk of SCD or ventricular arrhythmias.

Original languageEnglish (US)
Pages (from-to)251-256
Number of pages6
JournalHeart and Lung: Journal of Acute and Critical Care
Volume42
Issue number4
DOIs
StatePublished - Jul 1 2013

Keywords

  • Arrhythmias
  • Dietary supplements
  • Fish oil
  • Sudden cardiac death

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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    Khoueiry, G., Abi Rafeh, N., Sullivan, E., Saiful, F., Jaffery, Z., Kenigsberg, D. N., Krishnan, S. C., Khanal, S., Bekheit, S., & Kowalski, M. (2013). Do omega-3 polyunsaturated fatty acids reduce risk of sudden cardiac death and ventricular arrhythmias? A meta-analysis of randomized trials. Heart and Lung: Journal of Acute and Critical Care, 42(4), 251-256. https://doi.org/10.1016/j.hrtlng.2013.03.006