Does heparin improve survival in experimental porcine gram-negative septic shock?

M. P. Griffin, Dennis Gore, J. B. Zwischenberger, T. E. Lobe, M. Hall, D. L. Traber, David Herndon

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

To evaluate the effect of heparin on gram-negative septic shock, immature piglets were subjected to fecal Escherichia coli peritonitis. One group of animals received a continuous infusion of heparin 25 units/kg/hr, while the control animals were given an equivalent voluem of lactated Ringer's solution. Heparin-treated animals (n = 5) had a mean survival time (± SEM) of 18.8 ± 2.2 hr vs. 11.9 ± 2.8 (P < 0.05) in controls (n = 5). Animals receiving heparin tended to have improved hemodynamic profiles and less leukopenia than controls.

Original languageEnglish (US)
Pages (from-to)343-349
Number of pages7
JournalCirculatory Shock
Volume31
Issue number3
StatePublished - 1990

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Septic Shock
Heparin
Swine
Leukopenia
Peritonitis
Hemodynamics
Escherichia coli

Keywords

  • Anticoagulation
  • Escherichia coli
  • Peritonitis
  • Piglets
  • Sepsis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Griffin, M. P., Gore, D., Zwischenberger, J. B., Lobe, T. E., Hall, M., Traber, D. L., & Herndon, D. (1990). Does heparin improve survival in experimental porcine gram-negative septic shock? Circulatory Shock, 31(3), 343-349.

Does heparin improve survival in experimental porcine gram-negative septic shock? / Griffin, M. P.; Gore, Dennis; Zwischenberger, J. B.; Lobe, T. E.; Hall, M.; Traber, D. L.; Herndon, David.

In: Circulatory Shock, Vol. 31, No. 3, 1990, p. 343-349.

Research output: Contribution to journalArticle

Griffin, MP, Gore, D, Zwischenberger, JB, Lobe, TE, Hall, M, Traber, DL & Herndon, D 1990, 'Does heparin improve survival in experimental porcine gram-negative septic shock?', Circulatory Shock, vol. 31, no. 3, pp. 343-349.
Griffin MP, Gore D, Zwischenberger JB, Lobe TE, Hall M, Traber DL et al. Does heparin improve survival in experimental porcine gram-negative septic shock? Circulatory Shock. 1990;31(3):343-349.
Griffin, M. P. ; Gore, Dennis ; Zwischenberger, J. B. ; Lobe, T. E. ; Hall, M. ; Traber, D. L. ; Herndon, David. / Does heparin improve survival in experimental porcine gram-negative septic shock?. In: Circulatory Shock. 1990 ; Vol. 31, No. 3. pp. 343-349.
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