Does heparin improve survival in experimental porcine gram-negative septic shock?

M. P. Griffin, D. C. Gore, J. B. Zwischenberger, T. E. Lobe, M. Hall, D. L. Traber, D. N. Herndon

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


To evaluate the effect of heparin on gram-negative septic shock, immature piglets were subjected to fecal Escherichia coli peritonitis. One group of animals received a continuous infusion of heparin 25 units/kg/hr, while the control animals were given an equivalent voluem of lactated Ringer's solution. Heparin-treated animals (n = 5) had a mean survival time (± SEM) of 18.8 ± 2.2 hr vs. 11.9 ± 2.8 (P < 0.05) in controls (n = 5). Animals receiving heparin tended to have improved hemodynamic profiles and less leukopenia than controls.

Original languageEnglish (US)
Pages (from-to)343-349
Number of pages7
JournalCirculatory Shock
Issue number3
StatePublished - 1990


  • Anticoagulation
  • Escherichia coli
  • Peritonitis
  • Piglets
  • Sepsis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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