Does serum Vitamin D status influence high-sensitivity c-reactive protein and gensini score in established coronary artery disease individuals

A. P. Shaheena, Poornima A. Manjrekar, Vivian D'souza, Padmanabh Kamath, M. S. Rukmini, Vinod Chandran, Durgarao Yalla, Mukund Prathivadibhayankaram

Research output: Contribution to journalArticle

Abstract

Introduction: Over the years, the extraskeletal effects of Vitamin D (vit D) are gaining prominence. The role of vit D deficiency (VDD) in coronary artery disease (CAD) is conflicting. Hence, the present study was aimed to correlate serum vit D levels with high-sensitivity C-reactive protein (hs-CRP) and Gensini score in CAD individuals. Materials and Methods: This cross-sectional study was conducted on 70 angiographically proven CAD individuals aged between 35 and 55 years of both sexes who presented with a history of myocardial injury or ischemia for the first time. The angiographic findings were graded using Gensini score. Serum vit D and hs-CRP were estimated using enzyme-linked immunosorbent assay. Results: The average serum vit D level was 15 ng/mL, and the ratio of diabetes and nondiabetes individuals was 52:18. Among the 70 patients, 66% (n = 46) were deficient, 20% (n = 14) were insufficient, and 14% (n = 10) had normal vit D status. Although insignificant, vit D levels had negative correlation with Gensini score (r = -0.17, P = 0.14) and hs-CRP levels (r = -0.03, P = 0.77) which was not sustained after multivariate logistic regression. A significant negative correlation (r = -0.35, P = 0.01) was found between serum vit D status and duration of diabetes. Conclusion: VDD observed in diabetes individuals is inversely related to the duration of diabetes which incidentally is associated with CAD. Thus, screening for vit D status may be vital for the management of CAD particularly in diabetes individuals.

Original languageEnglish (US)
Pages (from-to)197-201
Number of pages5
JournalJournal of Natural Science, Biology and Medicine
Volume10
Issue number2
DOIs
StatePublished - Jul 1 2019
Externally publishedYes

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Keywords

  • Coronary artery disease
  • Gensini score
  • high-sensitivity C-reactive protein
  • Vitamin D

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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