Does the addition of unconjugated estriol in maternal serum screening improve the detection of trisomy 21? A meta-analysis

E. R. Smith, J. Petersen, Anthony Okorodudu, M. G. Bissell

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

At present there is controversy over the addition of unconjugated estriol to maternal serum screening for trisomy 21. To resolve the controversy, we posed the hypothesis that there is no difference in sensitivity or specificity between a triple screen (α-fetoprotein, human chorionic gonadotropin, and unconjugated estriol) and a double screen (α-fetoprotein and human chorionic gonadotropin) in detecting a fetus with Down's syndrome. To test the hypotheses we conducted an analysis of prospective studies in the available literature. This technique was used because the occurrence of trisomy 21 is a rare event in pregnancy, making it difficult to arrive at a definitive conclusion on the basis of a single study. Using the statistical technique of meta-analysis, we have determined that the addition of unconjugated estriol does improve the detection of trisomy 21.

Original languageEnglish (US)
Pages (from-to)176-181
Number of pages6
JournalClinical Laboratory Management Review
Volume10
Issue number2
StatePublished - 1996

Fingerprint

Estriol
Down Syndrome
Meta-Analysis
Mothers
Fetal Proteins
Chorionic Gonadotropin
Serum
Fetus
Prospective Studies
Sensitivity and Specificity
Pregnancy

ASJC Scopus subject areas

  • Leadership and Management

Cite this

Does the addition of unconjugated estriol in maternal serum screening improve the detection of trisomy 21? A meta-analysis. / Smith, E. R.; Petersen, J.; Okorodudu, Anthony; Bissell, M. G.

In: Clinical Laboratory Management Review, Vol. 10, No. 2, 1996, p. 176-181.

Research output: Contribution to journalArticle

@article{8312b3bbb0b04721bb084372807bd062,
title = "Does the addition of unconjugated estriol in maternal serum screening improve the detection of trisomy 21? A meta-analysis",
abstract = "At present there is controversy over the addition of unconjugated estriol to maternal serum screening for trisomy 21. To resolve the controversy, we posed the hypothesis that there is no difference in sensitivity or specificity between a triple screen (α-fetoprotein, human chorionic gonadotropin, and unconjugated estriol) and a double screen (α-fetoprotein and human chorionic gonadotropin) in detecting a fetus with Down's syndrome. To test the hypotheses we conducted an analysis of prospective studies in the available literature. This technique was used because the occurrence of trisomy 21 is a rare event in pregnancy, making it difficult to arrive at a definitive conclusion on the basis of a single study. Using the statistical technique of meta-analysis, we have determined that the addition of unconjugated estriol does improve the detection of trisomy 21.",
author = "Smith, {E. R.} and J. Petersen and Anthony Okorodudu and Bissell, {M. G.}",
year = "1996",
language = "English (US)",
volume = "10",
pages = "176--181",
journal = "Clinical laboratory management review : official publication of the Clinical Laboratory Management Association / CLMA",
issn = "0888-7950",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Does the addition of unconjugated estriol in maternal serum screening improve the detection of trisomy 21? A meta-analysis

AU - Smith, E. R.

AU - Petersen, J.

AU - Okorodudu, Anthony

AU - Bissell, M. G.

PY - 1996

Y1 - 1996

N2 - At present there is controversy over the addition of unconjugated estriol to maternal serum screening for trisomy 21. To resolve the controversy, we posed the hypothesis that there is no difference in sensitivity or specificity between a triple screen (α-fetoprotein, human chorionic gonadotropin, and unconjugated estriol) and a double screen (α-fetoprotein and human chorionic gonadotropin) in detecting a fetus with Down's syndrome. To test the hypotheses we conducted an analysis of prospective studies in the available literature. This technique was used because the occurrence of trisomy 21 is a rare event in pregnancy, making it difficult to arrive at a definitive conclusion on the basis of a single study. Using the statistical technique of meta-analysis, we have determined that the addition of unconjugated estriol does improve the detection of trisomy 21.

AB - At present there is controversy over the addition of unconjugated estriol to maternal serum screening for trisomy 21. To resolve the controversy, we posed the hypothesis that there is no difference in sensitivity or specificity between a triple screen (α-fetoprotein, human chorionic gonadotropin, and unconjugated estriol) and a double screen (α-fetoprotein and human chorionic gonadotropin) in detecting a fetus with Down's syndrome. To test the hypotheses we conducted an analysis of prospective studies in the available literature. This technique was used because the occurrence of trisomy 21 is a rare event in pregnancy, making it difficult to arrive at a definitive conclusion on the basis of a single study. Using the statistical technique of meta-analysis, we have determined that the addition of unconjugated estriol does improve the detection of trisomy 21.

UR - http://www.scopus.com/inward/record.url?scp=0030001681&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030001681&partnerID=8YFLogxK

M3 - Article

VL - 10

SP - 176

EP - 181

JO - Clinical laboratory management review : official publication of the Clinical Laboratory Management Association / CLMA

JF - Clinical laboratory management review : official publication of the Clinical Laboratory Management Association / CLMA

SN - 0888-7950

IS - 2

ER -