Does the route of feeding modify the inflammatory response?

Alfred A. Santos, Mary L. Rodrick, Danny O. Jacobs, Charles A. Dinarello, Sheldon M. Wolff, John A. Mannick, Douglas W. Wilmore

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objective: The authors compared the responses to endotoxin in enterally and parenterally fed human volunteers. Background: Recent investigations have reported that the response to endotoxin in humans is greater in individuals who receive parenteral nutrition rather than enteral feeding. It was proposed that this difference was related to gut barrier dysfunction during intravenous nutrition. To evaluate this hypothesis, the authors analyzed the responses of human subjects to an intravenously administered bolus of endotoxin after enteral or parenteral nutrition. Methods: Fifteen randomly selected healthy volunteers were studied during two separate investigations; ten studies were performed in ten subjects who received enteral nutrition, and nine studies were carried out in five additional subjects who received parenteral nutrition. After 2 days of enteral feedings or 7 days of parenteral feedings, endotoxin was administered by intravenous injection; temperature, symptom score, and duration then were measured serially. Blood samples were obtained for leukocyte and platelet count, and plasma concentrations of corticotrophin, cortisol, epinephrine, norepinephrine, tumor necrosis factor, and interleukin-6. Mononuclear cell response to phytohemagglutinin was determined at 0, 4, and 24 hours. Results: In the parenteral group, a diminished response was observed in platelet count and plasma interleukin-6 levels compared with volunteers who received enteral nutrition. The duration of symptoms tended to be reduced in the parenterally fed group, although this did not achieve significance. Other responses were not significantly different between the two groups. Conclusion: The responses to endotoxin in human subjects who received parenteral nutrition were similar compared with subjects who received enteral nutrition, although platelet count and plasma interleukin-6 concentration were diminished.

Original languageEnglish (US)
Pages (from-to)155-163
Number of pages9
JournalAnnals of Surgery
Volume220
Issue number2
StatePublished - Aug 1994
Externally publishedYes

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Enteral Nutrition
Parenteral Nutrition
Endotoxins
Platelet Count
Interleukin-6
Volunteers
Phytohemagglutinins
Leukocyte Count
Intravenous Injections
Adrenocorticotropic Hormone
Epinephrine
Hydrocortisone
Norepinephrine
Healthy Volunteers
Tumor Necrosis Factor-alpha
Temperature

ASJC Scopus subject areas

  • Surgery

Cite this

Santos, A. A., Rodrick, M. L., Jacobs, D. O., Dinarello, C. A., Wolff, S. M., Mannick, J. A., & Wilmore, D. W. (1994). Does the route of feeding modify the inflammatory response? Annals of Surgery, 220(2), 155-163.

Does the route of feeding modify the inflammatory response? / Santos, Alfred A.; Rodrick, Mary L.; Jacobs, Danny O.; Dinarello, Charles A.; Wolff, Sheldon M.; Mannick, John A.; Wilmore, Douglas W.

In: Annals of Surgery, Vol. 220, No. 2, 08.1994, p. 155-163.

Research output: Contribution to journalArticle

Santos, AA, Rodrick, ML, Jacobs, DO, Dinarello, CA, Wolff, SM, Mannick, JA & Wilmore, DW 1994, 'Does the route of feeding modify the inflammatory response?', Annals of Surgery, vol. 220, no. 2, pp. 155-163.
Santos AA, Rodrick ML, Jacobs DO, Dinarello CA, Wolff SM, Mannick JA et al. Does the route of feeding modify the inflammatory response? Annals of Surgery. 1994 Aug;220(2):155-163.
Santos, Alfred A. ; Rodrick, Mary L. ; Jacobs, Danny O. ; Dinarello, Charles A. ; Wolff, Sheldon M. ; Mannick, John A. ; Wilmore, Douglas W. / Does the route of feeding modify the inflammatory response?. In: Annals of Surgery. 1994 ; Vol. 220, No. 2. pp. 155-163.
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N2 - Objective: The authors compared the responses to endotoxin in enterally and parenterally fed human volunteers. Background: Recent investigations have reported that the response to endotoxin in humans is greater in individuals who receive parenteral nutrition rather than enteral feeding. It was proposed that this difference was related to gut barrier dysfunction during intravenous nutrition. To evaluate this hypothesis, the authors analyzed the responses of human subjects to an intravenously administered bolus of endotoxin after enteral or parenteral nutrition. Methods: Fifteen randomly selected healthy volunteers were studied during two separate investigations; ten studies were performed in ten subjects who received enteral nutrition, and nine studies were carried out in five additional subjects who received parenteral nutrition. After 2 days of enteral feedings or 7 days of parenteral feedings, endotoxin was administered by intravenous injection; temperature, symptom score, and duration then were measured serially. Blood samples were obtained for leukocyte and platelet count, and plasma concentrations of corticotrophin, cortisol, epinephrine, norepinephrine, tumor necrosis factor, and interleukin-6. Mononuclear cell response to phytohemagglutinin was determined at 0, 4, and 24 hours. Results: In the parenteral group, a diminished response was observed in platelet count and plasma interleukin-6 levels compared with volunteers who received enteral nutrition. The duration of symptoms tended to be reduced in the parenterally fed group, although this did not achieve significance. Other responses were not significantly different between the two groups. Conclusion: The responses to endotoxin in human subjects who received parenteral nutrition were similar compared with subjects who received enteral nutrition, although platelet count and plasma interleukin-6 concentration were diminished.

AB - Objective: The authors compared the responses to endotoxin in enterally and parenterally fed human volunteers. Background: Recent investigations have reported that the response to endotoxin in humans is greater in individuals who receive parenteral nutrition rather than enteral feeding. It was proposed that this difference was related to gut barrier dysfunction during intravenous nutrition. To evaluate this hypothesis, the authors analyzed the responses of human subjects to an intravenously administered bolus of endotoxin after enteral or parenteral nutrition. Methods: Fifteen randomly selected healthy volunteers were studied during two separate investigations; ten studies were performed in ten subjects who received enteral nutrition, and nine studies were carried out in five additional subjects who received parenteral nutrition. After 2 days of enteral feedings or 7 days of parenteral feedings, endotoxin was administered by intravenous injection; temperature, symptom score, and duration then were measured serially. Blood samples were obtained for leukocyte and platelet count, and plasma concentrations of corticotrophin, cortisol, epinephrine, norepinephrine, tumor necrosis factor, and interleukin-6. Mononuclear cell response to phytohemagglutinin was determined at 0, 4, and 24 hours. Results: In the parenteral group, a diminished response was observed in platelet count and plasma interleukin-6 levels compared with volunteers who received enteral nutrition. The duration of symptoms tended to be reduced in the parenterally fed group, although this did not achieve significance. Other responses were not significantly different between the two groups. Conclusion: The responses to endotoxin in human subjects who received parenteral nutrition were similar compared with subjects who received enteral nutrition, although platelet count and plasma interleukin-6 concentration were diminished.

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