Donor site wound protein synthesis correlates with length of acute hospitalization in severely burned children

Demidmaa Tuvdendorj, David L. Chinkes, Xiao Jun Zhang, Asle Aarsland, David Herndon

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Autografting of burn wounds results in generation of donor site wounds. Here we measured donor site wound protein fractional synthesis rate (FSR) in a burn pediatric population and showed that FSR increases over time postsurgery and correlates with the length of hospital stay (LOS) normalized for total body surface area (TBSA) burn size. 3.9 ± 1.1 days after the grafting surgery patients participated in a metabolic study consisting of continuous infusion of l-[ring-2H5]-phenylalanine and donor site wound punch biopsies. Donor site wound protein FSR was 10.4 ± 7.5%/day. Wound FSR demonstrated linear correlation with the time postsurgery (p<0.05). Multiple regression analysis showed that LOS/TBSA correlated with donor site wound protein FSR and time postsurgery (p<0.001) and the following equation describes the relationship: estimated LOS/TBSA=(FSR-12.95-1.414 × postsurgery day)/(-17.8). This equation predicted that FSR corrected for the postsurgery day when the metabolic study was conducted accounted for 67% of the variability (r2=0.673) in the LOS/TBSA. Donor site wound protein FSR correlated to LOS/TBSA of burn patients admitted to the intensive care unit. Measurement of protein deposition in regenerating donor site wound using stable isotope technique provides a quantitative measure of wound healing.

Original languageEnglish (US)
Pages (from-to)277-283
Number of pages7
JournalWound Repair and Regeneration
Volume18
Issue number3
DOIs
StatePublished - 2010

Fingerprint

Length of Stay
Hospitalization
Tissue Donors
Body Surface Area
Wounds and Injuries
Proteins
Autologous Transplantation
Phenylalanine
Isotopes
Wound Healing
Intensive Care Units
Regression Analysis
Pediatrics
Biopsy
Population

ASJC Scopus subject areas

  • Dermatology
  • Surgery
  • Medicine(all)

Cite this

Donor site wound protein synthesis correlates with length of acute hospitalization in severely burned children. / Tuvdendorj, Demidmaa; Chinkes, David L.; Zhang, Xiao Jun; Aarsland, Asle; Herndon, David.

In: Wound Repair and Regeneration, Vol. 18, No. 3, 2010, p. 277-283.

Research output: Contribution to journalArticle

Tuvdendorj, Demidmaa ; Chinkes, David L. ; Zhang, Xiao Jun ; Aarsland, Asle ; Herndon, David. / Donor site wound protein synthesis correlates with length of acute hospitalization in severely burned children. In: Wound Repair and Regeneration. 2010 ; Vol. 18, No. 3. pp. 277-283.
@article{7c818c2dd2fb470e9d549ebec00bb7c3,
title = "Donor site wound protein synthesis correlates with length of acute hospitalization in severely burned children",
abstract = "Autografting of burn wounds results in generation of donor site wounds. Here we measured donor site wound protein fractional synthesis rate (FSR) in a burn pediatric population and showed that FSR increases over time postsurgery and correlates with the length of hospital stay (LOS) normalized for total body surface area (TBSA) burn size. 3.9 ± 1.1 days after the grafting surgery patients participated in a metabolic study consisting of continuous infusion of l-[ring-2H5]-phenylalanine and donor site wound punch biopsies. Donor site wound protein FSR was 10.4 ± 7.5{\%}/day. Wound FSR demonstrated linear correlation with the time postsurgery (p<0.05). Multiple regression analysis showed that LOS/TBSA correlated with donor site wound protein FSR and time postsurgery (p<0.001) and the following equation describes the relationship: estimated LOS/TBSA=(FSR-12.95-1.414 × postsurgery day)/(-17.8). This equation predicted that FSR corrected for the postsurgery day when the metabolic study was conducted accounted for 67{\%} of the variability (r2=0.673) in the LOS/TBSA. Donor site wound protein FSR correlated to LOS/TBSA of burn patients admitted to the intensive care unit. Measurement of protein deposition in regenerating donor site wound using stable isotope technique provides a quantitative measure of wound healing.",
author = "Demidmaa Tuvdendorj and Chinkes, {David L.} and Zhang, {Xiao Jun} and Asle Aarsland and David Herndon",
year = "2010",
doi = "10.1111/j.1524-475X.2010.00584.x",
language = "English (US)",
volume = "18",
pages = "277--283",
journal = "Wound Repair and Regeneration",
issn = "1067-1927",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Donor site wound protein synthesis correlates with length of acute hospitalization in severely burned children

AU - Tuvdendorj, Demidmaa

AU - Chinkes, David L.

AU - Zhang, Xiao Jun

AU - Aarsland, Asle

AU - Herndon, David

PY - 2010

Y1 - 2010

N2 - Autografting of burn wounds results in generation of donor site wounds. Here we measured donor site wound protein fractional synthesis rate (FSR) in a burn pediatric population and showed that FSR increases over time postsurgery and correlates with the length of hospital stay (LOS) normalized for total body surface area (TBSA) burn size. 3.9 ± 1.1 days after the grafting surgery patients participated in a metabolic study consisting of continuous infusion of l-[ring-2H5]-phenylalanine and donor site wound punch biopsies. Donor site wound protein FSR was 10.4 ± 7.5%/day. Wound FSR demonstrated linear correlation with the time postsurgery (p<0.05). Multiple regression analysis showed that LOS/TBSA correlated with donor site wound protein FSR and time postsurgery (p<0.001) and the following equation describes the relationship: estimated LOS/TBSA=(FSR-12.95-1.414 × postsurgery day)/(-17.8). This equation predicted that FSR corrected for the postsurgery day when the metabolic study was conducted accounted for 67% of the variability (r2=0.673) in the LOS/TBSA. Donor site wound protein FSR correlated to LOS/TBSA of burn patients admitted to the intensive care unit. Measurement of protein deposition in regenerating donor site wound using stable isotope technique provides a quantitative measure of wound healing.

AB - Autografting of burn wounds results in generation of donor site wounds. Here we measured donor site wound protein fractional synthesis rate (FSR) in a burn pediatric population and showed that FSR increases over time postsurgery and correlates with the length of hospital stay (LOS) normalized for total body surface area (TBSA) burn size. 3.9 ± 1.1 days after the grafting surgery patients participated in a metabolic study consisting of continuous infusion of l-[ring-2H5]-phenylalanine and donor site wound punch biopsies. Donor site wound protein FSR was 10.4 ± 7.5%/day. Wound FSR demonstrated linear correlation with the time postsurgery (p<0.05). Multiple regression analysis showed that LOS/TBSA correlated with donor site wound protein FSR and time postsurgery (p<0.001) and the following equation describes the relationship: estimated LOS/TBSA=(FSR-12.95-1.414 × postsurgery day)/(-17.8). This equation predicted that FSR corrected for the postsurgery day when the metabolic study was conducted accounted for 67% of the variability (r2=0.673) in the LOS/TBSA. Donor site wound protein FSR correlated to LOS/TBSA of burn patients admitted to the intensive care unit. Measurement of protein deposition in regenerating donor site wound using stable isotope technique provides a quantitative measure of wound healing.

UR - http://www.scopus.com/inward/record.url?scp=77952280872&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952280872&partnerID=8YFLogxK

U2 - 10.1111/j.1524-475X.2010.00584.x

DO - 10.1111/j.1524-475X.2010.00584.x

M3 - Article

VL - 18

SP - 277

EP - 283

JO - Wound Repair and Regeneration

JF - Wound Repair and Regeneration

SN - 1067-1927

IS - 3

ER -