Dopamine D1 receptor mediation of the discriminative stimulus properties of SKF 38393

Kathryn Cunningham, Patrick M. Callahan, James B. Appel

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Dopaminergic mediation of the stimulus properties of SKF 38393 was analyzed in a two-lever, drug discrimination task. After acquiring the ability to discriminate SKF 38393 (10 mg/kg) from saline, rats (N = 12) were given substitution (generalization) and combination (antagonism) tests with selective D1 and D2 receptor agonists and antagonists. The D2 agonists apomorphine and Ly 171555 (levo-isomer of Ly 141865) produced predominantly saline-lever responding; the D1 antagonist Sch 23390, but not the D2 antagonist haloperidol, dose dependently antagonized the SKF 38393 cue. These data support previous neurochemical and behavioral research which suggest that SKF 38393 may act by stimulating D1 receptors.

Original languageEnglish (US)
Pages (from-to)121-125
Number of pages5
JournalEuropean Journal of Pharmacology
Volume119
Issue number1-2
DOIs
StatePublished - Dec 10 1985
Externally publishedYes

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Keywords

  • D receptors
  • SKF 38393

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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