Dopaminergic agents for the treatment of cocaine abuse

Miles P. Smith, Alexander Hoepping, Kenneth M. Johnson, Monika Trzcinska, Alan P. Kozikowski

Research output: Contribution to journalReview article

43 Scopus citations

Abstract

Cocaine is a major drug of abuse whose devastating effects have captured the attention of health officials and policy makers. Based upon the alarming health and crime-related costs associated with the use of this powerful reinforcing drug, immediate therapies are needed for the treatment of cocaine addiction. In this review, some of the small-molecule-based approaches that have been pursued in the search for such medications are highlighted. Because the pharmacological actions of cocaine stem laargely from its ability to block the dopamine transporter, many intervention strategies have focused on the dopaminergic pathway. Copyright (C) 1999 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)322-332
Number of pages11
JournalDrug Discovery Today
Volume4
Issue number7
DOIs
StatePublished - Jul 1 1999

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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    Smith, M. P., Hoepping, A., Johnson, K. M., Trzcinska, M., & Kozikowski, A. P. (1999). Dopaminergic agents for the treatment of cocaine abuse. Drug Discovery Today, 4(7), 322-332. https://doi.org/10.1016/S1359-6446(99)01332-X