Dose dependence and time course of smoke inhalation injury in a rabbit model

A. Bidani, H. K. Hawkins, C. Z. Wang, T. A. Heming

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The dose dependence and time course of smoke inhalation injury were determined in a rabbit model. Animals were insufflated with 18-90 breaths of cotton smoke or room air (control) at a rate of 18 breaths/min and tidal volume of 12 ml/kg. Smoke-exposed animals exhibited dose-related histologic effects with progressive deterioration of respiratory function during the postexposure period of observation (96 h). The smoke-exposed rabbits had reproducible injuries to both airway mucosa and lung parenchyma, manifested by disruption and sloughing of airway and alveolar epithelia, and exudation of protein-rich fluid and leukocytes into the airway and alveolar spaces. Significant effects were evident by 24 h postexposure. Smoke inhalation also affected the respiratory burst of alveolar macrophages. Generation of superoxide anions by alveolar macrophages at 48 h postexposure was increased significantly after smoke inhalation (54 breaths). The present rabbit model should be useful for studying the interactions between pulmonary epithelial cells and leukocytes after smoke inhalation and for determining the role that abnormal functioning of alveolar macrophages plays in the development of smoke inhalation injury.

Original languageEnglish (US)
Pages (from-to)111-122
Number of pages12
JournalLung
Volume177
Issue number2
StatePublished - 1999

Fingerprint

Smoke Inhalation Injury
Smoke
Rabbits
Alveolar Macrophages
Inhalation
Leukocytes
Lung
Respiratory Burst
Tidal Volume
Superoxides
Mucous Membrane
Epithelium
Epithelial Cells
Air
Observation
Wounds and Injuries

Keywords

  • Alveolar macrophage
  • Lung pathology
  • Pulmonary functions

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology

Cite this

Bidani, A., Hawkins, H. K., Wang, C. Z., & Heming, T. A. (1999). Dose dependence and time course of smoke inhalation injury in a rabbit model. Lung, 177(2), 111-122.

Dose dependence and time course of smoke inhalation injury in a rabbit model. / Bidani, A.; Hawkins, H. K.; Wang, C. Z.; Heming, T. A.

In: Lung, Vol. 177, No. 2, 1999, p. 111-122.

Research output: Contribution to journalArticle

Bidani, A, Hawkins, HK, Wang, CZ & Heming, TA 1999, 'Dose dependence and time course of smoke inhalation injury in a rabbit model', Lung, vol. 177, no. 2, pp. 111-122.
Bidani A, Hawkins HK, Wang CZ, Heming TA. Dose dependence and time course of smoke inhalation injury in a rabbit model. Lung. 1999;177(2):111-122.
Bidani, A. ; Hawkins, H. K. ; Wang, C. Z. ; Heming, T. A. / Dose dependence and time course of smoke inhalation injury in a rabbit model. In: Lung. 1999 ; Vol. 177, No. 2. pp. 111-122.
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