Double trouble: Co-occurrence of testosterone deficiency and body fatness associated with all-cause mortality in US men

David Lopez, X. Qiu, S. Advani, K. K. Tsilidis, M. Khera, J. Kim, A. Morgentaler, R. Wang, S. Canfield

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Background: Testosterone deficiency (TD, total testosterone ≤350 ng/dL [12.15 nmol L−1]) and obesity epidemic are growing in parallel in the United States. Yet, the sequelae of TD and obesity on the risk of mortality remain unclear. Objective: To investigate whether the co-occurrence of TD and overall obesity (body mass index ≥30 kg/m2), and abdominal obesity (waist circumference ≥102 cm), is associated with a risk of all-cause mortality in American men. Design: The data were obtained from the NHANES 1999-2004 and the Linked Mortality File (December 31, 2011). A total of 948 participants aged ≥20 years old with endogenous sex hormones and adiposity measurements data were included in this study. Results: Over a median of 9.5 years of follow-up, 142 men died of any cause in this cohort. Multivariable analysis showed a 2.60 fold increased risk of death among men with TD compared with men without TD (Hazard Ratio [HR] = 2.60; 95% confidence interval [CI] = 1.20-5.80). No evidence for interaction between TD and overall or abdominal obesity with risk of death (Pinteraction ≥.80). However, only after comparing men with TD and abdominal obesity with men without TD and no abdominal obesity, we found a 3.30 fold increased risk of death (HR = 3.30, 95% CI = 1.21-8.71). Conclusion: Men with co-occurrence of TD and abdominal obesity have a higher risk of mortality. The effect of co-occurrence of TD and abdominal obesity should be further explored with a larger and longer follow-up time study.

Original languageEnglish (US)
Pages (from-to)58-65
Number of pages8
JournalClinical Endocrinology
Volume88
Issue number1
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

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Keywords

  • all-cause mortality
  • obesity and NHANES
  • testosterone

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Lopez, D., Qiu, X., Advani, S., Tsilidis, K. K., Khera, M., Kim, J., Morgentaler, A., Wang, R., & Canfield, S. (2018). Double trouble: Co-occurrence of testosterone deficiency and body fatness associated with all-cause mortality in US men. Clinical Endocrinology, 88(1), 58-65. https://doi.org/10.1111/cen.13501