Down-regulation of pancreatic growth and gallbladder contractility by bile salts

Guillermo Gomez, Courtney Townsend, Roya Maani, Pomila Singh, George G. Greeley, James C. Thompson

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Luminal sequestration of bile salts with cholestyramine and the oral administration of bile salts represent current forms of therapy for some diseases. We have recently reported that secretion of these salts exerts negative feedback control on the release of cholecystokinin (CCK). The purpose of this study was to examine the effects of long-term alterations of luminal concentrations of bile salts on CCK target organs, the pancreas and gallbladder. The bile salt pool in adult guinea pigs was either enriched by feeding 0.5 percent sodium taurocholate or depleted by feeding 2 percent cholestyramine. Pancreatic growth, gallbladder contractility, the concentration of cholecystokinin receptors in the gallbladder muscle, and meal-stimulated plasma levels of cholecystokinin were significantly stimulated by feeding the bile salt sequestrant cholestyramine to guinea pigs. Administration of the bile salt taurocholate produced the opposite effects. Inhibition of CCK release by bile salts and up-regulation of CCK receptors by CCK may be the mechanisms responsible for the actions of bile salts on CCK target organs.

Original languageEnglish (US)
Pages (from-to)20-26
Number of pages7
JournalThe American Journal of Surgery
Volume157
Issue number1
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Gallbladder
Bile Acids and Salts
Cholecystokinin
Down-Regulation
Growth
Cholestyramine Resin
Cholecystokinin Receptors
Taurocholic Acid
Guinea Pigs
Oral Administration
Meals
Pancreas
Up-Regulation
Salts
Muscles

ASJC Scopus subject areas

  • Surgery

Cite this

Down-regulation of pancreatic growth and gallbladder contractility by bile salts. / Gomez, Guillermo; Townsend, Courtney; Maani, Roya; Singh, Pomila; Greeley, George G.; Thompson, James C.

In: The American Journal of Surgery, Vol. 157, No. 1, 1989, p. 20-26.

Research output: Contribution to journalArticle

Gomez, Guillermo ; Townsend, Courtney ; Maani, Roya ; Singh, Pomila ; Greeley, George G. ; Thompson, James C. / Down-regulation of pancreatic growth and gallbladder contractility by bile salts. In: The American Journal of Surgery. 1989 ; Vol. 157, No. 1. pp. 20-26.
@article{714590ddf3e54ab4809c96e1d08317d1,
title = "Down-regulation of pancreatic growth and gallbladder contractility by bile salts",
abstract = "Luminal sequestration of bile salts with cholestyramine and the oral administration of bile salts represent current forms of therapy for some diseases. We have recently reported that secretion of these salts exerts negative feedback control on the release of cholecystokinin (CCK). The purpose of this study was to examine the effects of long-term alterations of luminal concentrations of bile salts on CCK target organs, the pancreas and gallbladder. The bile salt pool in adult guinea pigs was either enriched by feeding 0.5 percent sodium taurocholate or depleted by feeding 2 percent cholestyramine. Pancreatic growth, gallbladder contractility, the concentration of cholecystokinin receptors in the gallbladder muscle, and meal-stimulated plasma levels of cholecystokinin were significantly stimulated by feeding the bile salt sequestrant cholestyramine to guinea pigs. Administration of the bile salt taurocholate produced the opposite effects. Inhibition of CCK release by bile salts and up-regulation of CCK receptors by CCK may be the mechanisms responsible for the actions of bile salts on CCK target organs.",
author = "Guillermo Gomez and Courtney Townsend and Roya Maani and Pomila Singh and Greeley, {George G.} and Thompson, {James C.}",
year = "1989",
doi = "10.1016/0002-9610(89)90414-5",
language = "English (US)",
volume = "157",
pages = "20--26",
journal = "American Journal of Surgery",
issn = "0002-9610",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Down-regulation of pancreatic growth and gallbladder contractility by bile salts

AU - Gomez, Guillermo

AU - Townsend, Courtney

AU - Maani, Roya

AU - Singh, Pomila

AU - Greeley, George G.

AU - Thompson, James C.

PY - 1989

Y1 - 1989

N2 - Luminal sequestration of bile salts with cholestyramine and the oral administration of bile salts represent current forms of therapy for some diseases. We have recently reported that secretion of these salts exerts negative feedback control on the release of cholecystokinin (CCK). The purpose of this study was to examine the effects of long-term alterations of luminal concentrations of bile salts on CCK target organs, the pancreas and gallbladder. The bile salt pool in adult guinea pigs was either enriched by feeding 0.5 percent sodium taurocholate or depleted by feeding 2 percent cholestyramine. Pancreatic growth, gallbladder contractility, the concentration of cholecystokinin receptors in the gallbladder muscle, and meal-stimulated plasma levels of cholecystokinin were significantly stimulated by feeding the bile salt sequestrant cholestyramine to guinea pigs. Administration of the bile salt taurocholate produced the opposite effects. Inhibition of CCK release by bile salts and up-regulation of CCK receptors by CCK may be the mechanisms responsible for the actions of bile salts on CCK target organs.

AB - Luminal sequestration of bile salts with cholestyramine and the oral administration of bile salts represent current forms of therapy for some diseases. We have recently reported that secretion of these salts exerts negative feedback control on the release of cholecystokinin (CCK). The purpose of this study was to examine the effects of long-term alterations of luminal concentrations of bile salts on CCK target organs, the pancreas and gallbladder. The bile salt pool in adult guinea pigs was either enriched by feeding 0.5 percent sodium taurocholate or depleted by feeding 2 percent cholestyramine. Pancreatic growth, gallbladder contractility, the concentration of cholecystokinin receptors in the gallbladder muscle, and meal-stimulated plasma levels of cholecystokinin were significantly stimulated by feeding the bile salt sequestrant cholestyramine to guinea pigs. Administration of the bile salt taurocholate produced the opposite effects. Inhibition of CCK release by bile salts and up-regulation of CCK receptors by CCK may be the mechanisms responsible for the actions of bile salts on CCK target organs.

UR - http://www.scopus.com/inward/record.url?scp=0024548629&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024548629&partnerID=8YFLogxK

U2 - 10.1016/0002-9610(89)90414-5

DO - 10.1016/0002-9610(89)90414-5

M3 - Article

VL - 157

SP - 20

EP - 26

JO - American Journal of Surgery

JF - American Journal of Surgery

SN - 0002-9610

IS - 1

ER -