Down regulation of the high-affinity IgE receptor associated with successful treatment of chronic idiopathic urticaria with omalizumab

Michael C. Saavedra, Sanjiv Sur

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Chronic idiopathic urticaria is a condition that is often controllable with antihistamine therapy. However, some patients have disease burden that is difficult to manage, non-responsive to antihistamines and often requires immunosuppressive medications such as corticosteroids or cyclosporine. We present here a study that demonstrates the effectiveness of omalizumab in treating this condition and the temporal relationship between improvement and down regulation of the high affinity IgE receptor (FceRI). For this, blood samples were obtained from a symptomatic patient before each treatment and processed for flow cytometric analysis of FceRI levels on the surface of blood basophils. Down regulation of FceRI was observed in association with significant clinical improvement and discontinuation of immunosuppressive medications.

Original languageEnglish (US)
Article number2
JournalClinical and Molecular Allergy
Volume9
DOIs
StatePublished - Jan 19 2011

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IgE Receptors
Histamine Antagonists
Urticaria
Immunosuppressive Agents
Down-Regulation
Basophils
Cyclosporine
Adrenal Cortex Hormones
Therapeutics
Omalizumab

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Molecular Biology

Cite this

Down regulation of the high-affinity IgE receptor associated with successful treatment of chronic idiopathic urticaria with omalizumab. / Saavedra, Michael C.; Sur, Sanjiv.

In: Clinical and Molecular Allergy, Vol. 9, 2, 19.01.2011.

Research output: Contribution to journalArticle

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