@article{5a03e5bca905494691309a72f1d0e840,
title = "Drosophila model of anti-retroviral therapy induced peripheral neuropathy and nociceptive hypersensitivity",
abstract = "The success of antiretroviral therapy (ART) has improved the survival of HIV-infected patients significantly. However, significant numbers of patients on ART whose HIV disease is well controlled show peripheral sensory neuropathy (PSN), suggesting that ART may cause PSN. Although the nucleoside reverse transcriptase inhibitors (NRTIs), one of the vital components of ART, are thought to contribute to PSN, the mechanisms underlying the PSN induced by NRTIs are unclear. In this study, we developed a Drosophila model of NRTI-induced PSN that recapitulates the salient features observed in patients undergoing ART: PSN and nociceptive hypersensitivity. Furthermore, our data demonstrate that pathways known to suppress PSN induced by chemotherapeutic drugs are ineffective in suppressing the PSN or nociception induced by NRTIs. Instead, we found that increased dynamics of a peripheral sensory neuron may possibly underlie NRTI-induced PSN and nociception. Our model provides a solid platform in which to investigate further mechanisms of ART-induced PSN and nociceptive hypersensitivity.",
keywords = "Dendrites, HIV, NRTI, Stability, Synapse",
author = "Bush, {Keegan M.} and Barber, {Kara R.} and Martinez, {Jade A.} and Tang, {Shao Jun} and Wairkar, {Yogesh P.}",
note = "Funding Information: We are grateful to the members of Michael Galko lab and the Tang lab for the design of Von Frey filaments. We are indebted to Dr Michael Galko and his team especially, Yan Wang for helping us perform the heat probe nociception assays. We are also thankful to Ms. Bianca Gozales for help with the project. Finally, we would like to thank Dr Raji Natarajan for scientific edits. Keegan Bush was supported by a fellowship from the neuroscience and cell biology department of UTMB and Mitchell center for neurodegenerative diseases. We are also thankful for funding from the NINDS R56NS105681, Alzheimer{\textquoteright}s Association NTF award, and STARs award from the UT system to Y.P.W. S.-J.T. was supported by NIH grants: R01NS095747, R01NS079166, R01DA036165. National Institutes of Health https://dx.doi.org/10.13039/100000002 R56NS105681; Alzheimer{\textquoteright}s Association https://dx.doi.org/10.13039/100000957 AARG-NTF-643643. Funding Information: Keegan Bush was supported by a fellowship from the neuroscience and cell biology department of UTMB and Mitchell center for neurodegenerative diseases. We are also thankful for funding from the NINDS R56NS105681, Alzheimer{\textquoteright}s Association NTF award, and STARs award from the UT system to Y.P.W. S.-J.T. was supported by NIH grants: R01NS095747, R01NS079166, R01DA036165. National Institutes of Health https://dx.doi.org/10.13039/100000002 R56NS105681; Alzheimer{\textquoteright}s Association https://dx.doi.org/10.13039/100000957 AARG-NTF-643643. Publisher Copyright: {\textcopyright} 2021. Published by The Company of Biologists Ltd",
year = "2021",
month = jan,
doi = "10.1242/bio.054635",
language = "English (US)",
volume = "10",
journal = "Biology Open",
issn = "2046-6390",
publisher = "Company of Biologists Ltd",
number = "1",
}