Drug-induced linear immunoglobulin a bullous dermatosis mimicking Stevens-Johnson syndrome: A case report

Julie E. Cummings; Renee R. Snyder; Erica B. Kelly; Sharon S. Raimer

Drug-induced linear immunoglobulin a bullous dermatosis mimicking Stevens-Johnson syndrome: A case report

Julie E. Cummings, Renee R. Snyder, Erica B. Kelly, Sharon S. Raimer

Dermatology

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Abstract

Linear immunoglobulin A (IgA) bullous dermatosis (LABD) is a rare autoimmune disorder characterized by vesiculobullous mucocutaneous eruptions. LABD also has been reported as a drug-induced reaction. Idiopathic LABD and drug-induced LABD re clinically indistinguishable and can resemble bullous pemphigoid, dermatitis herpetiformis, or bullous erythema multiforme. LABD is diagnosed with direct immunofluorescence (DIF), and idiopathic LABD can be distinguished from drug-induced LABD with a careful medication history. We present the case of a 54-year-old man with drug-induced LABD after ingestion of rimantadine, zanamivir, and azithromycin for presumed influenza. The patient's bullous eruption resolved with discontinuation of the offending medications and treatment with prednisone and pentoxlfylline.

Original language	English (US)
Pages (from-to)	203-207
Number of pages	5
Journal	Cutis
Volume	79
Issue number	3
State	Published - Mar 1 2007

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Dermatology

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Cummings, J. E., Snyder, R. R., Kelly, E. B., & Raimer, S. S. (2007). Drug-induced linear immunoglobulin a bullous dermatosis mimicking Stevens-Johnson syndrome: A case report. Cutis, 79(3), 203-207.

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abstract = "Linear immunoglobulin A (IgA) bullous dermatosis (LABD) is a rare autoimmune disorder characterized by vesiculobullous mucocutaneous eruptions. LABD also has been reported as a drug-induced reaction. Idiopathic LABD and drug-induced LABD re clinically indistinguishable and can resemble bullous pemphigoid, dermatitis herpetiformis, or bullous erythema multiforme. LABD is diagnosed with direct immunofluorescence (DIF), and idiopathic LABD can be distinguished from drug-induced LABD with a careful medication history. We present the case of a 54-year-old man with drug-induced LABD after ingestion of rimantadine, zanamivir, and azithromycin for presumed influenza. The patient's bullous eruption resolved with discontinuation of the offending medications and treatment with prednisone and pentoxlfylline.",

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Drug-induced linear immunoglobulin a bullous dermatosis mimicking Stevens-Johnson syndrome: A case report

Abstract

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